Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia

A technology of clozapine and nitrogen anesthesia, which is applied in the field of medicine, can solve problems such as central nervous system dysfunction, diving diseases or diving accidents, and affect the safety of diving operations, so as to achieve quick results, alleviate and improve the symptoms of central nervous system hyperexcitability, Improvement of neurobehavioral symptoms

Active Publication Date: 2022-06-28
NANTONG UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the diving process, if nitrogen anesthesia occurs, it will cause central nervous system dysfunction, easily lead to other diving diseases or diving accidents, affect the safety of diving operations, and even lead to more serious consequences
However, there are currently no drugs for this

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia
  • Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia
  • Application of N-clozapine oxide in preparation of medicine for preventing and treating nitrogen anesthesia

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment

[0019] N-Clozapine can significantly improve the abnormal state of central nervous system in nitrogen anesthetized mice

[0020] (1) Control group: 0.1 ml of normal saline was injected into the mouse intraperitoneal cavity. After 30 minutes, the mice were placed in a hyperbaric chamber with air or nitrogen-oxygen mixture to pressurize to a pressure of 200 m to simulate the abnormal excitation symptoms of the nitrogen anesthesia center in divers. The voluntary movement trajectories of the mice were recorded and the distance of movement was analyzed to evaluate the severity of the central hyperexcitability of the mice.

[0021] (2) N-Clozapine Oxide treatment group: inject 0.2mg / kg, 1mg / kg, 1.5mg / kg, 2mg / kg of N-Clozapine Oxide into mice intraperitoneally, 30 minutes later, placed under high pressure The cabin was pressurized to a pressure of 200 m with air or nitrox, and the abnormal state of the central nervous system of the mice was evaluated by recording the voluntary moveme...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of medicines, and discloses application of N-clozapine oxide in preparation of a medicine for preventing and treating nitrogen anesthesia. The N-clozapine oxide is given through the abdominal cavity, so that the abnormal central excitation symptom occurring in the diving process of compressed air or nitrogen-oxygen mixed gas can be improved, and the N-clozapine oxide has the advantages of being quick in effect taking, obvious in effect, convenient to use and the like. As the N-clozapine oxide is a metabolite of a clinically common medicine clozapine, the clinical popularization risk of the invention is low.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a new use of Clozapine N-oxide (N-clozapine oxide), in particular to the application of N-clozapine oxide in the preparation of a medicine for preventing and treating nitrogen anesthesia. Background technique [0002] Nitrogen narcosis is a pathophysiology characterized by emotional, intellectual, and cognitive impairments, as well as motor and sensory impairments, when diving with compressed air or nitrogen-oxygen mixtures to a depth of 30 m or greater. state. Since this state is similar to the clinical application of general anesthesia or drunkenness, it is called nitrogen anesthesia. Nitrogen anesthesia recovers quickly after being released from the high-pressure nitrogen environment, and generally does not cause serious harm to human health and life. However, in the course of diving, if nitrogen anesthesia occurs, it will cause dysfunction of the central nervous system, easil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5513A61P25/00
CPCA61K31/5513A61P25/00Y02A50/30
Inventor 彭彬高永静
Owner NANTONG UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com