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Application of semiliquidambar cathayensis or semiliquidambar cathayensis extract in preparation of anti-cerebral ischemia drugs

A technology of anti-cerebral ischemia and Banfenghe, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., to improve neurological function, reduce the size of cerebral infarction, and facilitate administration

Pending Publication Date: 2022-06-10
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing literature shows that Banfenghe has rich pharmacological activities, and can be used to prepare drugs for anti-hepatitis B virus, promoting blood circulation and removing blood stasis, anti-inflammatory and analgesic, and treating osteoarthritis. At present, there are no related reports

Method used

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  • Application of semiliquidambar cathayensis or semiliquidambar cathayensis extract in preparation of anti-cerebral ischemia drugs
  • Application of semiliquidambar cathayensis or semiliquidambar cathayensis extract in preparation of anti-cerebral ischemia drugs
  • Application of semiliquidambar cathayensis or semiliquidambar cathayensis extract in preparation of anti-cerebral ischemia drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] drug test

[0033] Approach:

Embodiment 2

[0034] (1) Neurobehavioral score

[0035] Result: if Figure 1-3 As shown, compared with the sham operation group, the neurobehavioral score, cerebral infarction rate and brain water content of rats in the model group were significantly increased ( P P P P P P P Figure 4 shown. Note: ## P ** P ** P <0.01 vs. model group.

Embodiment 3

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PUM

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Abstract

The invention discloses application of semiliquidambar cathayensis or an extract of the semiliquidambar cathayensis in preparation of an anti-cerebral ischemia drug, the semiliquidambar cathayensis is a dry root of hamamelis hamamelis H.T.Chang., the extract of the semiliquidambar cathayensis is an aqueous extract of the semiliquidambar cathayensis or an organic solvent extract of the semiliquidambar cathayensis, and an extraction method of the extract of the semiliquidambar cathayensis comprises the following steps: taking the semiliquidambar cathayensis; adding a solvent for soaking treatment, then heating for extraction, combining liquid medicine extracted for multiple times, and concentrating to obtain the traditional Chinese medicine composition. It is found for the first time that the semiliquidambar cathayensis or the extract of the semiliquidambar cathayensis has the obvious effect of relieving cerebral ischemia injury, the semiliquidambar cathayensis or the extract of the semiliquidambar cathayensis has the patent medicine potential of preparing the medicine preparation for preventing or treating cerebral ischemia and related diseases, and the preparation method of the medicine preparation is simple, low in cost and good in

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the application of a kind of maple lotus or its extract in the preparation of anti-cerebral ischemia medicine. Background technique [0002] Stroke includes ischemic stroke and hemorrhagic stroke, and ischemic stroke accounts for about 60%-80%. Ischemic stroke is a focal brain dysfunction caused by insufficient or interrupted local cerebral blood supply, oxygen supply, etc. The disease is a common clinical critical illness and frequently-occurring disease, often with a poor prognosis and high morbidity, disability and mortality. At present, there is still no effective method to treat or delay cerebral ischemic injury. Ischemia-reperfusion injury (IRI) refers to the pathological phenomenon in which tissue damage is aggravated after a certain period of ischemia and blood supply is restored. The brain tissue hypoxia and ischemia-reperfusion caused ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P9/10A61K125/00
CPCA61K36/185A61P9/10A61K2236/331A61K2236/39A61K2236/51A61K2236/333
Inventor 韦洁何俊慧方伟蓉李冬梅韦桂宁韦冬梅李懿
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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