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Medicine for treating psoriasis

A technology for psoriasis and drugs, applied in the direction of drug combination, application, skin diseases, etc., can solve problems such as expensive

Pending Publication Date: 2022-06-07
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of these biological agents is very good, but the price is expensive. At present, the long-term curative effect of these biological agents is still in the stage of clinical research. Therefore, there is still an urgent need to develop systemic therapeutic drugs with significant curative effect, less toxicity and low price.

Method used

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  • Medicine for treating psoriasis
  • Medicine for treating psoriasis
  • Medicine for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Mice grouping and administration

[0026] Sixty SPF clean-grade female BALB / c mice, 6 to 8 weeks old, weighing approximately 20 g were used. Shave the back hair and remove any remaining hair with a depilatory cream. An area of ​​2 cm × 3 cm of the skin was exposed, and acclimation was cultured for 3 days.

[0027] Then the mice were randomly divided into 6 groups with 10 mice in each group. The grouping and administration methods were as follows:

[0028] Control group: apply vaseline cream every day, 1 time every day, for 7 consecutive days, and form a negative control with imiquine cream.

[0029] Model group: 5% imiquimod (IMQ) cream (for inducing psoriasis) 62.5 mg / mice / day was applied to the back of mice, once a day for 7 consecutive days.

[0030] Administration group 1; Raphalin low-dose group (25 mg / kg), 5% imiquimod cream 62.5 mg / mice / day was applied to the back of the mice, once a day for 7 consecutive days. Then, the concentration of 2.5 mg / mL raphanin...

Embodiment 2

[0055] Raphalin (purity higher than 95%) was first dissolved in DMSO, prepared into a 40 mM stock solution and placed in a refrigerator at minus 80 degrees, and the incomplete medium was used for gradient dilution to different concentrations for use in experiments.

[0056] 1. Cell Growth Activity Assay

[0057] Human immortalized keratinocytes were cultured, and when the cells grew to the logarithmic growth phase, the cells were inoculated on a 96-well plate, with a seeding density of 5000 cells / space, and a seeding volume of 100 μL. Incubate for 24h in a 37°C incubator with 5% carbon dioxide. The final concentrations of 32 μM, 28 μM, 24 μM, 20 μM, 16 μM, 12 μM, 8 μM and 4 μM medicated medium were then prepared. The complete medium was discarded, and 100 μL of the above-mentioned drug-containing medium was added to each empty space for incubation for 24h, 48h and 72h, and DMSO was used as a negative control. After the corresponding time point, 10 μL of CCK8 was added to eac...

Embodiment 3

[0064] 1. Case selection

[0065] In line with the diagnostic criteria of traditional Chinese and Western medicine for psoriasis: 100 patients in this group, 67 males and 33 females; aged 18 to 65 years old, with an average age of (34.6±2.2) years old; the course of disease was from 1 month to 7 years, with an average course of (3.4±2.2) years. 1.5) years; patients who did not systematically use traditional Chinese medicine, glucocorticoids, or immunosuppressive therapy 1 month before treatment; patients with skin lesions less than 30% of the body surface area (ie, PASI score between 5-10).

[0066] 2. Medication method

[0067] All patients were divided into two groups according to the random number table method:

[0068] Treatment group (50 people): the control group was treated with raphanin for symptomatic treatment, 20 mg each time, 3 times a day. 4 weeks of medication as a course of treatment, 1-3 courses of treatment.

[0069] Control group (50 people): The control gro...

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Abstract

The invention discloses a medicine for treating psoriasis and belongs to the field of natural medicines. A series of experiments show that the sulforaphene relieves epidermal hyperplasia and inflammatory response of a psoriasis-like mouse skin lesion part induced by imiquimod; excessive proliferation of human keratinocytes is inhibited, and cell apoptosis is promoted; the symptoms of the psoriasis are relieved, and an obvious treatment effect on the psoriasis is achieved. The sulforaphene is separated from brassica plants including but not limited to radish, broccoli, cabbage, leaf mustard and horseradish, the components are natural and nontoxic, the psoriasis treatment effect is remarkable, the psoriasis is not prone to relapse after healing, and the sulforaphene has wide application prospects in preparation of the medicine for treating psoriasis.

Description

technical field [0001] This article relates to the application of a plant extract rapin in the preparation and treatment of psoriasis, which belongs to the natural field. Background technique [0002] Psoriasis, commonly known as psoriasis, is a common chronic immune inflammatory skin disease. The disease has the characteristics of long course, easy recurrence, and incurable. In some cases, it is not cured for life, which seriously affects the physical and mental health of patients. The disease is also a very common disease, with a prevalence of about 2%-4% of the world's population. In recent years, the incidence of psoriasis in my country has been increasing year by year, and most of them are young adults. Psoriasis is a skin disease caused by the interaction of genetic, environmental, immune and other factors. Typical pathological features are immune cell infiltration into the dermis and epidermal and epidermal hyperplasia found in the skin lesions of psoriasis patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/145A61K45/06A61K36/31A61K8/9789A61K8/46A61P17/06A23L33/00A23L19/00A61Q19/00
CPCA61K31/145A61K45/06A61K36/31A61K8/9789A61K8/46A61P17/06A23L33/00A23L19/00A61Q19/00A23V2002/00A23V2200/318Y02A50/30
Inventor 袁其朋贾路路
Owner BEIJING UNIV OF CHEM TECH
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