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Hemostatic quick-setting spray and preparation method thereof

A spray and rapid coagulation technology, applied in aerosol delivery, blood diseases, pharmaceutical formulations, etc., can solve the problem of inconvenient use of active hemostatic materials, and achieve the effects of shortened action time, stable product performance and convenient use.

Inactive Publication Date: 2022-06-03
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the technical problem of inconvenient use of the above-mentioned active hemostatic material, the object of the present invention is to provide a hemostatic quick-setting spray, the technical solution of which is:

Method used

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  • Hemostatic quick-setting spray and preparation method thereof
  • Hemostatic quick-setting spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 2 g of chitosan was dissolved in 100 mL of 0.2M acetic acid, and 100 mL of ethanol was added, followed by 364 uL of octanoic anhydride, and 2.38 g of EDC and 1.43 g of NHS. The reaction was overnight, and 3 mL of 5M sodium hydroxide was added to adjust the pH to 10, filtered, washed with water and ethanol for 5 times, and dried in a vacuum oven to obtain hydrophobically modified chitosan;

[0035] 2g of hydrophobically modified chitosan was dissolved in 100mL of 0.2M acetic acid, nitrogen was purged for 10 minutes, the pH was adjusted to 5.0, and then 1.19g of 3,4-dihydroxyphenylpropionic acid, 2.38g of EDC and 1.43 g of NHS were reacted overnight, dialyzed with acidified deionized water for 3 days, and freeze-dried to obtain a hydrophilic and hydrophobic co-grafted chitosan conjugate hemostatic and rapid coagulation material;

[0036] Dissolve 2 g of 1wt% chitosan conjugate hemostatic and rapid coagulation material in acetic acid, using dimethyl ether (DME) as a propel...

Embodiment 2

[0038] 2 g of chitosan was dissolved in 100 mL of 0.2M acetic acid, and 100 mL of ethanol was added, heated to 45°C, followed by 0.2 g of dodecanoic anhydride, and 2.38 g of EDC and 1.43 g of NHS. The reaction was overnight, and 3 mL of 5M sodium hydroxide was added to adjust the pH to 10, filtered, washed with water and ethanol for 5 times, and dried in a vacuum oven to obtain hydrophobically modified chitosan;

[0039] 2g of hydrophobically modified chitosan was dissolved in 100mL of 0.2M acetic acid, nitrogen was purged for 10 minutes, the pH was adjusted to 5.0, and then 1.19g of 3,4-dihydroxyphenylpropionic acid, 2.38g of EDC and 1.43 g of NHS were reacted overnight, dialyzed with acidified deionized water for 3 days, and freeze-dried to obtain a hydrophilic and hydrophobic co-grafted chitosan conjugate hemostatic and rapid coagulation material;

[0040] Dissolve 2 g of 1wt% chitosan conjugate hemostatic and rapid coagulation material in acetic acid, using dimethyl ether ...

Embodiment 3

[0042]2 g of chitosan was dissolved in 100 mL of 0.2M acetic acid, and 100 mL of ethanol was added, heated to 65°C, followed by 0.154 g of dodecanoic anhydride, and 2.38 g of EDC and 1.43 g of NHS. The reaction was overnight, and 3 mL of 5M sodium hydroxide was added to adjust the pH to 10, filtered, washed with water and ethanol for 5 times, and dried in a vacuum oven to obtain hydrophobically modified chitosan;

[0043] 2g of hydrophobically modified chitosan was dissolved in 100mL of 0.2M acetic acid, nitrogen was purged for 10 minutes, the pH was adjusted to 5.0, and then 1.19g of 3,4-dihydroxyphenylpropionic acid, 2.38g of EDC and 1.43 g of NHS were reacted overnight, dialyzed with acidified deionized water for 3 days, and freeze-dried to obtain a hydrophilic and hydrophobic co-grafted chitosan conjugate hemostatic and rapid coagulation material;

[0044] Dissolve 2 g of 1wt% chitosan conjugate hemostatic and rapid coagulation material in acetic acid, using dimethyl ether...

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Abstract

The invention discloses a hemostatic quick-setting spray and a preparation method thereof. The spray contains a hydrophilic and hydrophobic co-grafted polysaccharide conjugate, a solvent and an auxiliary agent, wherein the hydrophilic and hydrophobic co-grafted polysaccharide conjugate and the solvent have hydrophilicity and hydrophobicity at the same time and can react with all components in blood, so that blood gelatinization is promoted, the acting time of the hemostatic material and the blood components is effectively shortened, and wound healing is promoted; compared with a traditional mixed type co-grafted polysaccharide conjugate, due to the fact that a mixing step does not exist, hydrophilic and hydrophobic groups are distributed more evenly, and the product performance is more stable; the portable hemostatic spray is in the form of a spray, can be carried about, can be applied only by pressing the spray head during use, is more convenient to use compared with sponge, dressing plasters, hemostatic powder and the like, has low requirements on operating skills of operators, and is more suitable for emergency occasions such as car accidents, war wounds, natural disaster events and the like.

Description

technical field [0001] The invention relates to the field of medical consumables, in particular to a hemostatic and quick-setting spray and a preparation method thereof. Background technique [0002] Blood is an essential substance for human survival, and its main barrier is the skin tissue. When the skin is damaged by exogenous sources, its surface integrity will be destroyed and bleeding will occur. Massive blood loss caused by trauma can easily lead to insufficient tissue perfusion, disorder of cell metabolism, and multiple organ failure, which can lead to death. [0003] In some emergencies such as car accidents, war injuries and natural disasters, due to limited conditions, it is difficult to obtain systematic and timely treatment for traumatic blood loss. Therefore, the preparation of a hemostatic material that is convenient to use and quickly stops bleeding can greatly reduce the disability rate and mortality rate of patients with blood loss. [0004] At present, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61K9/12A61K47/08A61K31/722A61K31/716A61K31/728A61K31/734A61P7/04C08B37/08C08B37/00C08B37/04
CPCA61L24/08A61L24/001A61L24/0015A61K9/12A61K9/0014A61K47/08A61K31/722A61K31/716A61K31/728A61K31/734A61P7/04C08B37/003C08B37/0063C08B37/0072C08B37/0084A61L2400/04A61L2300/412C08L5/08C08L5/02C08L5/04
Inventor 职康康谭梓仪曲乐丰
Owner SHANGHAI CHANGZHENG HOSPITAL
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