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Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating nerve demyelinating diseases

A technology of nerve demyelination and growth factors, applied in the field of medicine

Pending Publication Date: 2022-05-10
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no relevant research to prove that IGFBP2 can treat demyelinated mental disorders

Method used

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  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating nerve demyelinating diseases
  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating nerve demyelinating diseases
  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating nerve demyelinating diseases

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Embodiment Construction

[0020] In order to describe the technical content of the present invention more clearly and verify the role of IGFBP2 in the treatment of nerve demyelinating diseases, further description will be given below in conjunction with specific examples.

[0021] Establishment of a demyelinating rat model

[0022] SD rats were housed in a 12-h light / dark rhythm environment with free access to water and food. All behavioral experiments were performed in the light rhythm of the animals.

[0023] Drug demyelination:

[0024] First, SD rats were used to establish the model, and isoflurane (R510-22, RWD China, 4-5% induction, 1-2% maintenance) was used to induce anesthesia. After deep anesthesia, 1 μL of 1% lysolecithin (LPC, Sigma-Aldrich) was dissolved in saline by surgery using a 33-gauge syringe needle (Hamilton) at the following stereoscopic coordinates, and the control group used the same volume of saline, and the liquid was injected into Bilateral to the mPFC: +2.7 mm; medial to ...

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Abstract

The invention relates to an application of insulin-like growth factor binding protein 2 in preparation of drugs for treating nerve demyelination diseases. The IGFBP2 intervention can significantly improve the myelination level, and improve mental symptoms caused by stress demyelination.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of an insulin-like growth factor binding protein 2 in the preparation of medicines for treating nerve demyelinating diseases. Background technique [0002] Myelin is a layer of membrane wrapped around the axons of nerve cells, that is, myelin is composed of Schwann cells and myelin cell membranes. Its role is to insulate, preventing the transmission of nerve electrical impulses from the axon of one neuron to the axon of another neuron. Demyelination refers to the damage to the myelin sheath that occurs after myelination. Demyelinating disease is a kind of acquired disease with different etiology and different clinical manifestations, but has similar characteristics. The characteristic pathological change is demyelination of nerve fibers while nerve cells remain relatively intact. Because normal conduction of nerve impulses depends on the insulating properties o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/30A61P25/22A61P25/24A61P25/28
CPCA61K38/30A61P25/22A61P25/24A61P25/28A61K38/1754A61P25/00
Inventor 王振史栋栋张瀛丹
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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