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Application of fructus gleditsiae in preparation of medicine for treating cerebral ischemia-reperfusion injury

A technology of cerebral ischemia-reperfusion and porcine tooth soap, which is applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., to inhibit the release of inflammatory factors, regulate nerve function, inhibit cell oxidative stress damage, and treat cerebral ischemia-reperfusion. damage effect

Pending Publication Date: 2022-05-10
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above-mentioned technical problems, the present invention provides the preparation of pig tooth soap and its application in the medicine for treating cerebral ischemia-reperfusion injury, and solves the problem of how to extract the volatile oil of pig tooth soap to treat cerebral ischemia-reperfusion injury

Method used

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  • Application of fructus gleditsiae in preparation of medicine for treating cerebral ischemia-reperfusion injury
  • Application of fructus gleditsiae in preparation of medicine for treating cerebral ischemia-reperfusion injury
  • Application of fructus gleditsiae in preparation of medicine for treating cerebral ischemia-reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Process:

[0031] Take an appropriate amount of pig tooth soap slices, cut them into pieces, weigh 100g accurately, add 10 times the amount of water, 10ml of n-hexane, steam distillation for 10 hours to get volatile oil, collect the volatile oil, add appropriate amount of anhydrous sodium sulfate to remove water, and let it stand overnight to get pig tooth Soap volatile oil.

[0032] Take 25 mg of the volatile oil of pig's tooth soap, add 3% Tween-80, and configure it into 10 ml of normal saline to obtain the volatile oil of pig's tooth soap nose drops.

[0033] Efficacy: Eliminate phlegm and resuscitate, dissipate stagnation and reduce swelling, treat cerebral ischemia-reperfusion injury (ischemic stroke).

[0034] How to use: Spray into nasal cavity with sprayer.

[0035] Dosage: 0.8ml / day (according to the 2020 edition of "Chinese Pharmacopoeia", the daily dosage of a pig tooth soap for adults is 1.5g and the extraction rate of volatile oil of pig tooth soap is 0.1...

Embodiment 2

[0037] Process:

[0038] Take an appropriate amount of pig tooth soap decoction pieces, cut it into pieces, weigh 100g accurately, add 8 times the amount of water, 5ml n-hexane, and steam distill for 6 hours to obtain volatile oil. Collect the volatile oil and add appropriate amount of anhydrous sodium sulfate to remove water, and let stand overnight to get pig tooth Soap volatile oil.

[0039] Take 25 mg of the volatile oil of pig's tooth soap, add 3% Tween-80, and configure it into 10 ml of normal saline to obtain the volatile oil of pig's tooth soap nose drops.

[0040] Efficacy: Eliminate phlegm and resuscitate, dissipate stagnation and reduce swelling, treat cerebral ischemia-reperfusion injury (ischemic stroke).

[0041] How to use: Spray into nasal cavity with sprayer.

[0042] Dosage: 0.8ml / day (according to the 2020 edition of "Chinese Pharmacopoeia", the daily dosage of a pig tooth soap for adults is 1.5g and the extraction rate of volatile oil of pig tooth soap is...

Embodiment 3

[0044] Process:

[0045] Take an appropriate amount of pig tooth soap decoction pieces, cut into pieces, weigh 100g accurately, add 12 times the amount of water, 15ml of n-hexane, and steam distill for 14 hours to obtain volatile oil, collect the volatile oil, add appropriate amount of anhydrous sodium sulfate to remove water, and let stand overnight to get pig tooth Soap volatile oil.

[0046] Take 25 mg of the volatile oil of pig's tooth soap, add 3% Tween-80, and configure it into 10 ml of normal saline to obtain the volatile oil of pig's tooth soap nose drops.

[0047]Efficacy: Eliminate phlegm and resuscitate, dissipate stagnation and reduce swelling, treat cerebral ischemia-reperfusion injury (ischemic stroke).

[0048] How to use: Spray into nasal cavity with sprayer.

[0049] Dosage: 0.8ml / day (according to the 2020 edition of "Chinese Pharmacopoeia", the daily dosage of a pig tooth soap for adults is 1.5g and the extraction rate of volatile oil of pig tooth soap is ...

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Abstract

The invention provides application of fructus gleditsiae volatile oil in preparation of a medicine for treating cerebral ischemia-reperfusion injury, and a preparation method of the fructus gleditsiae volatile oil comprises the following steps: taking a proper amount of fructus gleditsiae decoction pieces, adding water and normal hexane, performing steam distillation to obtain volatile oil, collecting the volatile oil, adding a proper amount of anhydrous sodium sulfate to remove water, and standing overnight to obtain the fructus gleditsiae volatile oil. The prepared fructus gleditsiae volatile oil acts on VEGFA, SRC, MAPK8, PIK3CA and TNF key targets through active ingredients of paeonol, linalool, methyleugenol, anethole and eugenol, adjusts multiple signal channels of sphingolipid, TNF and VEGF, inhibits oxidative stress injury of cells, inhibits release of inflammatory factors and regulates neural functions, so that the effect of treating cerebral ischemia-reperfusion injury is achieved; and a foundation is laid for further in-depth research on a'gui-freeing and resuscitation 'treatment action mechanism of the fructus gleditsiae.

Description

technical field [0001] The invention relates to a new application of the volatile oil of pig's tooth soap, in particular to the application of the volatile oil of pig's tooth soap in preparing a medicine for treating cerebral ischemia-reperfusion injury. Background technique [0002] The brain is the most sensitive organ of the human body to hypoxia. Brain tissue ischemia (ischemia) will cause damage to local brain tissue and its function. The degree of damage is related to the length of ischemia time and the amount of residual blood flow. Blood only causes reversible damage, while prolonged complete ischemia or severe ischemia can cause infarction. Histological changes The most obvious histological changes in the brain are cerebral edema and brain cell necrosis. Cerebral edema is the result of membrane lipid peroxidation that disrupts the structure of the membrane and dysfunction of the sodium pump. Pathophysiological mechanisms include: 1 free radicals and cerebral ische...

Claims

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Application Information

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IPC IPC(8): A61K36/483A61K31/12A61K31/085A61K31/045A61P9/10
CPCA61K36/483A61K31/12A61K31/085A61K31/045A61P9/10A61K2236/331A61K2300/00
Inventor 陈晓兰董娜娜邓铋莉
Owner 贵州中医药大学
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