Model construction of influence of endoplasmic reticulum stress on NLRP3 on myocardial ischemia
A technique for endoplasmic reticulum stress and myocardial ischemia, which can be used in preparations, material testing products, measuring devices and other directions for in vivo experiments, and can solve problems such as unclear mechanism of action
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment Construction
[0039] The following is further described in detail through specific implementation methods:
[0040] The embodiment is basically as attached figure 1 Shown: the effect of endoplasmic reticulum stress on NLRP3 in the construction of a model of myocardial ischemia The specific implementation process is as follows: the effect of endoplasmic reticulum stress on NLRP3 in the construction of a model of myocardial ischemia, using ligation / release of the left coronary artery in mice The descending artery and hypoxia and reoxygenation of cardiomyocytes were used to establish in vivo and in vitro models of myocardial ischemia-reperfusion injury, and then the content of calpain was adjusted during the experiment to change the stability of endoplasmic reticulum stress. The myocardial ischemia model of the changing process was continuously compared with the myocardial infarct size and the expression level of NLRP3 protein to realize the demonstration effect of the model.
[0041] (1) Imp...
PUM
![No PUM](https://static-eureka-patsnap-com.libproxy1.nus.edu.sg/ssr/23.2.0/_nuxt/noPUMSmall.5c5f49c7.png)
Abstract
Description
Claims
Application Information
![application no application](https://static-eureka-patsnap-com.libproxy1.nus.edu.sg/ssr/23.2.0/_nuxt/application.06fe782c.png)
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap