Application of gamma-glutamyltranspeptidase inhibitor GGsTop in preparation of medicine for treating acute attack of asthma and refractory asthma
A gamma glutamyl transpeptidase, acute attack technology, applied in the field of medicine, can solve problems such as poor effect of refractory asthma, achieve the effects of relieving the degree of acute attack, controlling refractory asthma, and reducing toxic and side effects
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[0022] The specific implementation manner of the present invention will be described in detail below in combination with specific situations.
[0023] The application of GGsTop, a γ-glutamyl transpeptidase inhibitor of the present invention, in the preparation of medicines for the treatment of acute attacks of asthma and refractory asthma was made by establishing mouse animal models. The specific mouse animal models are as follows: Figure 12 shown.
[0024] On the 0th day and the 7th day, chicken ovalbumin (OVA, 50ug) was injected intraperitoneally for sensitization, and on the 14th to 17th day, OVA solution (5 μg) was used to induce asthma every day, respectively, and on the 19th and 17th day 21 days of LPS (50ng) nasal drops induced asthma exacerbation, tracheal instillation of GGsTop (0.5mg / kg) on the 21st to 23rd day for treatment, 24 days later the treatment analysis proved that GGsTop is effective in the treatment of acute asthma attacks and refractory asthma drugs I...
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