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Application of gamma-glutamyltranspeptidase inhibitor GGsTop in preparation of medicine for treating acute attack of asthma and refractory asthma

A gamma glutamyl transpeptidase, acute attack technology, applied in the field of medicine, can solve problems such as poor effect of refractory asthma, achieve the effects of relieving the degree of acute attack, controlling refractory asthma, and reducing toxic and side effects

Pending Publication Date: 2022-04-29
杨明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the above situation, in order to overcome the shortcomings of existing anti-inflammatory drugs (glucocorticoids, etc.) and bronchodilator drugs (β2-adrenergic receptor agonists, etc.) The purpose of the invention is to provide the application of a gamma glutamyl transpeptidase inhibitor GGsTop in the preparation of drugs for the treatment of acute attacks of asthma and refractory asthma, which can effectively solve the problem of new medications for acute attacks of asthma and refractory asthma

Method used

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  • Application of gamma-glutamyltranspeptidase inhibitor GGsTop in preparation of medicine for treating acute attack of asthma and refractory asthma
  • Application of gamma-glutamyltranspeptidase inhibitor GGsTop in preparation of medicine for treating acute attack of asthma and refractory asthma
  • Application of gamma-glutamyltranspeptidase inhibitor GGsTop in preparation of medicine for treating acute attack of asthma and refractory asthma

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Embodiment Construction

[0022] The specific implementation manner of the present invention will be described in detail below in combination with specific situations.

[0023] The application of GGsTop, a γ-glutamyl transpeptidase inhibitor of the present invention, in the preparation of medicines for the treatment of acute attacks of asthma and refractory asthma was made by establishing mouse animal models. The specific mouse animal models are as follows: Figure 12 shown.

[0024] On the 0th day and the 7th day, chicken ovalbumin (OVA, 50ug) was injected intraperitoneally for sensitization, and on the 14th to 17th day, OVA solution (5 μg) was used to induce asthma every day, respectively, and on the 19th and 17th day 21 days of LPS (50ng) nasal drops induced asthma exacerbation, tracheal instillation of GGsTop (0.5mg / kg) on ​​the 21st to 23rd day for treatment, 24 days later the treatment analysis proved that GGsTop is effective in the treatment of acute asthma attacks and refractory asthma drugs I...

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Abstract

The invention relates to an application of a gamma-glutamyltranspeptidase inhibitor GGsTop in preparation of a medicine for treating acute attack of asthma and refractory asthma, which can effectively solve the new medication problem of acute attack of asthma and refractory asthma. The method comprises the following steps: establishing an animal model of acute asthma attack and refractory asthma by using cell wall components lipopolysaccharide and allergen of gram-negative bacteria, and adding GGsTop for treatment on the basis of inducing a mouse acute asthma attack and refractory asthma model by combining LPS and allergen. The treatment effect is judged by detecting indexes such as mouse airway hyperresponsiveness, lung tissue inflammation, bronchoalveolar lavage fluid and inflammatory factors, and application of the gamma-glutamyltranspeptidase inhibitor GGsTop in preparation of the medicine for treating acute attack of asthma and refractory asthma is achieved. The gamma-glutamyltranspeptidase inhibitor GGsTop can significantly relieve the acute attack degree of asthma, effectively controls refractory asthma, can replace glucocorticoid, and reduces the toxic and side effects caused by long-term clinical application of glucocorticoid.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of GGsTop, a gamma glutamyl transpeptidase inhibitor, in the preparation of medicines for treating acute attacks of asthma and refractory asthma. Background technique [0002] Asthma is a common chronic respiratory inflammatory disease, its main features are airway obstruction and bronchospasm, and the clinical manifestations of patients are mainly dyspnea and recurrent wheezing. Asthma is caused by complex environmental and genetic factors. The clinical manifestations of patients usually show extensive and variable reversible expiratory airflow limitation, resulting in recurrent symptoms such as wheezing, shortness of breath, chest tightness and / or coughing. The intensity changes with time, and usually occurs and intensifies at night and / or in the morning. If the diagnosis and treatment are not timely, irreversible airway narrowing and airway remodeling may occur with the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/662A61P11/06
CPCA61K31/662A61P11/06
Inventor 杨明张莉蓉韩立友李付广
Owner 杨明
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