Circulating reinfusion dialysis type circulating tumor cell in-vitro magnetic filtering device

Abstract

A circulating reinfusion dialysis type circulating tumor cell in-vitro magnetic filtering device comprises a magnetic separation pipe, a first magnet square matrix and a second magnet square matrix, the two ends of the magnetic separation pipe are connected with a first three-way valve and a second three-way valve through disassembly valves respectively, and the magnetic separation pipe is of a flat cylindrical structure; the first magnet square matrix and the second magnet square matrix can be two simple large magnets; the first magnet square matrix and the second magnet square matrix are arranged in parallel at intervals, and the magnetic separation pipe is positioned between the first magnet square matrix and the second magnet square matrix. According to the method, all large bottlenecks of existing CTCs detection are broken through, the whole process is easy to operate, and a large number of CTCs can be captured; compared with a blood sampling test, the method has the advantages that the yield is much higher, the method is much simpler than an in-vivo capture technology, a considerable number of living cells can be obtained compared with induction detection, and compared with pathological biopsy, puncture wounds can be avoided, the false negative rate is obviously reduced, and the heterogeneity of tumors can be better reflected.

Description

technical field [0001] The invention relates to the field of physics, in particular to measurement technology, in particular to a circulation-reinfusion dialysis type external magnetic filter device for circulating tumor cells (CTCs). Background technique [0002] Traditional tumor biopsy has the following problems: 1) There are risks and trauma in puncture; 2) The possibility of false negatives cannot be ruled out; 3) The puncture tissue is limited and cannot reflect tumor heterogeneity; 4) It is difficult to puncture some organs, such as the pancreas 5) Tumor changes need to be tracked, and repeated punctures are obviously impossible. Therefore, the limitation of the prior art proposes liquid biopsy to overcome the disadvantages mentioned above. In addition, the final cause of death of most cancer patients is tumor metastasis, especially hematogenous metastasis. CTCs happen to be the most direct and important link in the two aspects of liquid biopsy and hematogenous meta...

AI Technical Summary

Problems solved by technology

[0002] Traditional tumor biopsy has the following problems: 1) There are risks and trauma in puncture; 2) The possibility of false negatives cannot be ruled out; 3) The puncture tissue is limited and cannot reflect tumor heterogeneity; 4) It is difficult to puncture some organs, such as the pancreas cancer; 5) Tumor changes need to be tracked, and repeated punctures are obviously impossible

The main disadvantages are: the sample size is small when blood is drawn, and cells cannot be obtained by in vivo induction detection, and these defects are even more prominent for extremely rare targets such as circulating tumor cell clusters

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