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Application of fenofibrate as PPM1D agonist

A fenofibrate and agonist technology, applied in the field of medicine, can solve the problem of insufficient types of PPM1D agonists, achieve significant application effects and broaden the selection effect

Inactive Publication Date: 2022-04-22
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are insufficient types of PPM1D agonists that can be used clinically, and it is urgent to develop related applications of existing drugs

Method used

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  • Application of fenofibrate as PPM1D agonist
  • Application of fenofibrate as PPM1D agonist
  • Application of fenofibrate as PPM1D agonist

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Experimental program
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Embodiment Construction

[0028] The present invention will be described in further detail below in conjunction with the accompanying drawings, so that those skilled in the art can accurately understand the present invention.

[0029] [mutation comment]

[0030] Variants in PPM1D were functionally annotated by InterVar (version 4).

[0031] 【Experimental animals】

[0032] Male C57BL / 6 mice weighing 23-26 g at 8-10 weeks were raised under the following conditions: room temperature 22-24°C, humidity between 40-70%, alternating light and dark lighting for 12 hours, free access to water and food. Mice were divided into groups of wild-type groups (PPM1D + / + , WT) and the homozygous deficient group (PPM1D - / - , KO), and the number of mice in each group was 8. where PPM1D heterozygous mice (PPM1D + / - , HT) males and females were crossed to obtain PPM1D homozygous deficient mice (PPM1D - / - , KO).

[0033] 【MCAO model】

[0034] Anesthetize the mouse with chloral hydrate, make an incision along the midli...

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Abstract

The invention relates to application of fenofibrate as a PPM1D agonist and application of fenofibrate in promoting expression of regulatory gene mutation related to influence on vasoconstriction and arteriogenesis and activation of neutrophile granulocytes, microglia, neurons or endothelium. The invention widens the selection of the existing PPM1D agonist, and has a remarkable application effect in the field of neural immune medicines.

Description

technical field [0001] The application relates to the field of medical technology, in particular to the application of fenofibrate as a PPM1D agonist. Background technique [0002] Cerebral stroke, also known as stroke or cerebrovascular accident, is a group of acute cerebrovascular diseases with sudden onset and common features of focal neurological deficit. In recent years, its incidence rate is still rising, and it occurs more frequently in middle-aged and elderly people. It is one of the important killers that threaten human life and cause disability. DNA damage induced by cerebral ischemia plays a key role in neuronal cell death, neuroinflammation, neurovascular unit remodeling, and neurogenesis. The cell's DNA damage response (DDR) mechanism, which detects, signals, and promotes repair of DNA damage. However, the characterization of mutations in DNA damage response genes and their associated clinical outcomes in stroke patients remains unclear. The PPM1D gene encode...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P9/10A61P25/00
CPCA61K31/216A61P9/10A61P25/00
Inventor 施福东王拥军金薇娜孟霞贺文艳
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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