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Stable coronary heart disease onset risk assessment marker and application thereof

A risk assessment and stable technology, applied in the field of biomedicine to achieve the effect of improving the prediction accuracy

Active Publication Date: 2022-04-15
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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Problems solved by technology

[0005] However, in the prior art, there is no research report on the risk assessment of coronary heart disease by studying the characteristics of intestinal flora

Method used

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  • Stable coronary heart disease onset risk assessment marker and application thereof
  • Stable coronary heart disease onset risk assessment marker and application thereof
  • Stable coronary heart disease onset risk assessment marker and application thereof

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Embodiment Construction

[0126] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, the embodiments of the present invention will be further described in detail below in conjunction with the accompanying drawings. Here, the exemplary embodiments and descriptions of the present invention are used to explain the present invention, but not to limit the present invention.

[0127] As mentioned earlier, with the rapid development of various sequencing technologies such as metagenomics, massive amounts of data have also emerged. How to mine useful information from complex and redundant biological data for disease assessment, prediction, and diagnostic indicators has always been a very challenging task. With the advent of the era of big data, researchers have developed a variety of algorithms to mine relevant data in the field of life sciences, and for marker diagnostic models, machine learning algorithms have to be mentioned. Machine lear...

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Abstract

The invention discloses a stable coronary heart disease onset risk assessment marker and application thereof. The markers comprise bacteroides martensii, unclassified Eagle's bacilli, klebsiella pneumoniae, unclassified clostridium, unclassified pararevovirus, helicobacter sp. 5163FAA, anaerobic corynebacterium faecalis, unclassified biliphilic bacteria, human rosiberia, Eubacterium abdominalis, human body prevotella, pasteurella gut, wood anise bacilli, Eubacterium and unclassified megamonas. , bacillus pleurati, parabacterium and escherichia coli. According to the method, the onset risk of the stable coronary heart disease is predicted, and the prediction accuracy can be improved.

Description

technical field [0001] The present invention relates to the field of biomedical technology, in particular to stable coronary heart disease risk assessment markers and related applications. Background technique [0002] Cardiovascular disease mainly refers to coronary atherosclerotic heart disease, referred to as coronary heart disease (coronary artery disease, CAD). At present, the mainstream view is that cardiovascular disease, including coronary heart disease, is a type of immunometabolic disease, as well as a type of systemic, progressive, and inflammatory disease. The main lesion is atherosclerotic plaque formation and inflammatory progression, the essential features include lipid deposition and non-bacterial inflammatory response generated by inflammatory cell aggregation, which is called metabolic inflammation. Because in the process of atherosclerotic plaque and progression, various inflammatory cells and a large number of inflammatory mediators are always involved i...

Claims

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Application Information

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IPC IPC(8): G16H50/30G16B20/00
CPCG16H50/50G16H50/30G06N20/00Y02A90/10
Inventor 杨跃进朱海波杨进刚董超然许靖
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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