Deuterium-depleted water contact lens eye-moistening liquid and preparation method thereof
A technology of contact lenses and deuterium-depleted water is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Radiation protection and activation of immunity, avoid eye irritation, anti-aging effect
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Embodiment 1
[0029] The present embodiment provides a deuterium-depleted water contact lens ophthalmic solution.
[0030] Prepared from the following raw materials according to weight percentage: 0.01% boric acid, 0.5% immobilized hyaluronic acid, 0.01% phosphate buffer, 0.001% sodium octadecylsulfonate, 0.001% glycine, polyhexamethylene biguanide Acetate 0.000001%, the balance is deuterium-depleted water. The content of deuterium in the deuterium-depleted water is 110-145ppm.
[0031] Immobilized hyaluronic acid is prepared from the following raw materials by weight:
[0032] 1) chitosan is dissolved in 5wt% acetic acid solution to obtain 5wt% chitosan solution;
[0033] 2) dissolving shellac acid in ethanol to make a concentration of 3wt% shellac acid solution;
[0034] 3) dissolving hyaluronic acid in deionized water to obtain a 3wt% hyaluronic acid solution;
[0035] 4) Mix 100mL chitosan solution and 100mL shellac acid solution, then add 100mL hyaluronic acid solution, add genipin...
Embodiment 2
[0041] The present embodiment provides a deuterium-depleted water contact lens ophthalmic solution.
[0042]Prepared from the following raw materials according to weight percentage: glucose 3%, immobilized hyaluronic acid 2%, citrate buffer 5%, carbomer 1%, ethylenediaminetetraacetic acid 4%, sodium lactate 0.0001%, the balance It is deuterium-depleted water. The content of deuterium in the deuterium-depleted water is 90-110ppm.
[0043] Immobilized hyaluronic acid is prepared from the following raw materials by weight:
[0044] 1) chitosan is dissolved in 15wt% acetic acid solution to obtain 10wt% chitosan solution;
[0045] 2) dissolving shellac acid in ethanol to make a concentration of 7wt% shellac acid solution;
[0046] 3) dissolving hyaluronic acid in deionized water to obtain a 5wt% hyaluronic acid solution;
[0047] 4) Mix 100mL chitosan solution and 100mL shellac acid solution, then add 100mL hyaluronic acid solution, add genipin, the addition amount is 2wt% of t...
Embodiment 3
[0053] The present embodiment provides a deuterium-depleted water contact lens ophthalmic solution.
[0054] Prepared from the following raw materials according to weight percentage: 1.5% sodium chloride, 1% immobilized hyaluronic acid, 2% phosphate buffer, 0.5% Tween-80, 2% sodium edetate, 0.00005 sorbic acid %, the balance is deuterium-depleted water. The content of deuterium in the deuterium-depleted water is 50-90ppm.
[0055] Immobilized hyaluronic acid is prepared from the following raw materials by weight:
[0056] 1) chitosan is dissolved in 10wt% acetic acid solution to obtain 7wt% chitosan solution;
[0057] 2) dissolving shellac acid in ethanol to make a concentration of 5wt% shellac acid solution;
[0058] 3) dissolving hyaluronic acid in deionized water to obtain a 4wt% hyaluronic acid solution;
[0059] 4) Mix 100mL chitosan solution and 100mL shellac acid solution, then add 100mL hyaluronic acid solution, add genipin, the addition amount is 1wt% of the total...
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