Preparation process and device of selenized chitosan oligosaccharide and application of selenized chitosan oligosaccharide

Abstract

The invention belongs to the technical field of organic selenium preparation, and particularly relates to a preparation process and device of selenized chitosan oligosaccharide and application. Dissolving chitosan oligosaccharide in an acetic acid aqueous solution to obtain a chitosan oligosaccharide solution; sodium selenite is added into the chitosan oligosaccharide solution for ultrasonic treatment; carrying out centrifugal dialysis on the reacted mixed solution; carrying out suction filtration on the reaction concentrated solution, and then carrying out vacuum concentration on the filtrate obtained by suction filtration; adding absolute ethyl alcohol into the vacuum concentrated solution, standing after precipitate appears, performing centrifugal separation, washing the precipitate with absolute ethyl alcohol, and drying; the device comprises a rack, a stirring and mixing tank, a temperature control ultrasonic treatment tank, a centrifugal dialysis concentration device and a control box, according to the preparation device disclosed by the invention, the catalyst is the nickel particles attached to the heat dissipation fin group, the catalyst does not need to be filtered after the reaction, and the acetic acid smell easily emitted by the acetic acid can be completely filtered to remove peculiar smell and then is discharged, so that the reaction steps and the workshop environment are optimized.

Description

technical field [0001] The invention belongs to the technical field of organic selenium preparation, and in particular relates to a preparation process, device and application of selenized oligo-chitosan. Background technique [0002] As a cationic polysaccharide, chitosan has excellent biocompatibility, biodegradability, and no toxic side effects. Selenium is one of the essential trace elements for the human body. Selenium is mainly involved in metabolic pathways such as anti-oxidation, thyroid hormone synthesis and immune function in the body. The lack of selenium in the body can cause several chronic diseases such as cancer. With the further deepening of people's understanding of chitosan metal complexes, combined with the good biological activity of organic selenium compounds, more and more people have studied chitosan selenium. Oligomerization promotes the water solubility of chitosan, which is beneficial to promote absorption, and then maximize its biological activity...

AI Technical Summary

Problems solved by technology

The preparation process of the selenized chitosan oligosaccharide disclosed by this invention has simple steps, strong operability, and high selenium content in the product, but in the process of realizing its industrial production, the ultrasonic treatment in the second step will often reduce the temperature of the reaction solution increase, and when the temperature of sodium selenite is too high, selenous acid will decompose, which is unfavorable for the carrying out of the reaction, and the temperature increase will cause the further hydrolysis of oligomeric amino polysaccharides, thereby reducing the yield of the product. Therefore, the preparation process also often intermittently feeds nitrogen to reduce the temperature of the reaction solution during the production process.

But because the solvent of this reaction solution is acetic acid solution, and acetic acid solution has the property of volatilization, in carrying out the industrialized production process of above-mentioned selenized oligomeric amino polysaccharide, acetic acid solution tends to give off a pungent sour taste, and to react Nitrogen is passed into the solution, and the nitrogen can further take the acetic acid out of the reactor, making the whole workshop full of peculiar smell

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