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Extraction method for extracting compositae medicine components by using ionic liquid

A technology of ionic liquids and drugs, which is applied in the field of ionic liquids to extract the components of compositae drugs, can solve the problems of poor extraction effect, complicated methods, and residual harmful substances, and achieve the promotion of product generation, high extraction rate, and promotion of occasional extraction. chain reaction effect

Pending Publication Date: 2022-03-18
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been preliminary studies on the application of ionic liquids to extract other pharmaceutical ingredients, the existing extraction methods have problems such as poor extraction effect, complicated methods, and residual harmful substances.

Method used

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  • Extraction method for extracting compositae medicine components by using ionic liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Follow the steps below to extract the medicinal ingredients:

[0038] Step 1: pick and wash the peppercorns, dry them in a drier, sterilize them at high temperature and parasite eggs, crush them with a ball mill, and sieve them to obtain a medicinal powder with a particle size of 100 mesh.

[0039] Step 2: Mix the medicinal powder and the ionic liquid, ultrasonically treat for 30 minutes under the condition of ultrasonic power of 300W, cool to room temperature, let stand for two minutes, and stir thoroughly by magnetic force. The ionic liquid is taurine, N,N-dimethyl-N-(2-hydroxyethoxyethyl) ammonium propionate and histidine RCH (NH 2 )COOH is formed by mixing according to the molar ratio of 3:2:1.

[0040] Step 3: Centrifuge the mixture, centrifuge at a speed of 10000r / min for 15min to collect the supernatant, pass through an SPE column (C18) to remove the ionic liquid, wash with water and then elute with ethanol, and collect the eluted Blow dry with liquid nitrogen,...

Embodiment 2

[0043] Follow the steps below to extract the medicinal ingredients:

[0044] Step 1: pick and wash the pepper and mugwort leaves, dry them in a drier, sterilize them at high temperature and parasite eggs, crush them with a ball mill and sieve to obtain a medicinal powder with a particle size of 150 mesh.

[0045] Step 2: Mix the medicinal powder and the ionic liquid, ultrasonically treat it for 20-50 minutes under the condition of microwave power 118W, cool to room temperature, let it stand for two minutes, and fully stir it by magnetic force. The ionic liquid is composed of N,N-dimethyl-N-(2-hydroxyethoxyethyl)ammonium propionate and 1-ethyl-3-methylimidazole chloride in a molar ratio of 3:2.

[0046] Step 3: Centrifuge the mixture, and centrifuge at a speed of 10000r / min for 10 minutes to collect the supernatant, pass through an SPE column (C18) to remove the ionic liquid, wash with water and then elute with ethanol, and collect the eluted Blow dry with liquid nitrogen, add...

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Abstract

The invention discloses an extraction method for extracting compositae medicine components by ionic liquid, which comprises the following steps: step 1, cleaning, drying, crushing and screening compositae plants to obtain required medicine powder; 2, fully mixing ionic liquid with the medicinal powder obtained in the step 1, and reacting to obtain a mixture; and step 3, centrifugally separating the mixture obtained in the step 2, washing, eluting, drying, redissolving and centrifuging to obtain the required medicinal components. The method disclosed by the invention has selectivity and extraction yield on a target compound, and the extraction rate is high; the extraction method is simple and easy to implement, and the product is safe, non-toxic, green and environment-friendly.

Description

technical field [0001] The invention relates to the technical field of ionic liquid extraction, in particular to an extraction method for extracting compositae drug components by ionic liquid. Background technique [0002] In recent years, with the continuous improvement of detection technology and the country's emphasis on the research of Chinese herbal medicines, as a traditional Chinese herbal medicine, Polygonum sp. has anti-HIV activity and anti-tumor effects. In addition, it also has the effects of dispelling wind and dampness, dissipating blood stasis and relieving pain, detoxifying and reducing swelling, killing insects and relieving itching. It is often used in the treatment of dysentery, gastroenteritis, diarrhea, rheumatic joint pain, swelling and pain from bruises, dysfunctional uterine bleeding and other diseases; it is externally used for snake bites and skin eczema. At present, there are many research reports on active ingredients in China. Liu Xinping and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/282A61K36/28
CPCA61K36/282A61K36/28A61K2236/333A61K2236/53A61K2236/51
Inventor 罗江水魏润宏易滢婷周丰凯
Owner SICHUAN UNIV
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