Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of 3-phenylfuran substituted 2-phenyl-4H-benzo[1,3]oxazine derivative

A technology of phenylfuran and its derivatives, applied in the application field of medicine, can solve the problems of poor drug resistance, biological toxicity, incomplete curative effect, etc., and achieve the effect of reducing sodium current

Active Publication Date: 2022-02-15
SHENZHEN UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems existing in the existing technology, the present invention provides 2-phenyl-4H-benzo[1,3]oxazine derivatives substituted by 3-phenylfuran as sodium ion channel blockers in the preparation The application of drugs for the treatment of neuropathic pain aims to solve the problems of incomplete curative effect, poor drug resistance or biological toxicity of existing sodium ion blockers

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of 3-phenylfuran substituted 2-phenyl-4H-benzo[1,3]oxazine derivative
  • Application of 3-phenylfuran substituted 2-phenyl-4H-benzo[1,3]oxazine derivative
  • Application of 3-phenylfuran substituted 2-phenyl-4H-benzo[1,3]oxazine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] The present invention provides the application of 2-phenyl-4H-benzo[1,3]oxazine derivatives substituted by 3-phenylfuran as sodium ion channel blockers in the preparation of medicines for treating neuropathic pain. In order to make the object, technical solution and effect of the present invention more clear and definite, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0025] Sodium ion channel blockers have been widely used in the treatment of neuropathic pain. At present, the sodium ion channel subtypes in the treatment of neuropathic pain have low efficacy, are biotoxic to cells, and are not effective in relieving pain. . Based on this, the inventors have found that 2-phenyl-4H-benzo[1,3]oxazine derivatives substituted by 3-phenylfuran can effectively inhibit the current of sodium ion channels, an...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to application of a 3-phenylfuran substituted 2-phenyl-4H-benzo[1,3]oxazine derivative. The invention provides a sodion channel blocker. The sodion channel blocker is a 3-phenylfuran substituted 2-phenyl-4H-benzo[1,3]oxazine derivative. The compound can effectively inhibit a sodion channel and reduce sodium current, and has the potential of treating neuropathic pain, such as post-herpes zoster neuralgia, diabetic neuralgia, trigeminal neuralgia, spinal cord injury and the like.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to 2-phenyl-4H-benzo[1,3]oxazine derivatives substituted by 3-phenylfuran, which are used as sodium ion channel blockers in the preparation for treating neuropathic pain application in medicines. Background technique [0002] Sodium ion channels widely exist on the cell membrane of excitable cells such as skeletal muscle cells, cardiomyocytes, and nerve cells, and participate in the formation of action potentials of excitable cells. It is the main activation key of electrical signals, and electrical signals are the basis for the control of a series of physiological processes such as nerve activity and muscle contraction. In the human body, there are nine known subtypes of voltage-gated sodium ion channels, in different Eight subtypes are expressed in DRG (Dorsal root ganglia, dorsal root ganglia), and DRG neurons are the main sensory neurons. Sodium ion channel blockers have man...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D413/04C07D413/14A61P29/00A61P25/04A61K31/538
CPCC07D413/04C07D413/14A61P29/00A61P25/04Y02A50/30
Inventor 蔡松周浩杨豪毅王雨薇
Owner SHENZHEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com