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Flexible liposome with high ceramide loading capacity, and preparation method thereof

A flexible liposome and ceramide technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problem of lower ceramide utilization, low ceramide utilization, and poor ceramide stability and other problems, to achieve the effect of increasing transdermal absorption capacity, excellent repairing and anti-aging effect, and good stability

Pending Publication Date: 2022-02-11
ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, natural ceramide has a high melting point and low solubility, and is easy to crystallize or flocculate from cosmetic formulations, which not only affects the stability of the formulation, but also reduces the utilization rate of ceramide, which greatly limits its application.
Therefore, the existing technology has the problems of poor stability of ceramide and low utilization rate of ceramide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1. A flexible liposome with high ceramide load, comprising the following components in parts by weight: bakuchiol, 0.5-5 parts; ceramide NP, 6-10 parts; lecithin, 5-10 parts; hexyldecane Alcohol, 15-40 parts; dipotassium glycyrrhizinate, 0.5-3 parts; water, 32-73 parts.

[0020] Preferably, the following components are included in parts by weight: bakuchiol, 2 parts; ceramide NP, 8 parts; lecithin, 8 parts; hexyldecanol, 30 parts; dipotassium glycyrrhizinate, 1 part; share.

[0021] A method for preparing flexible liposomes with a high ceramide loading capacity, comprising the following steps:

[0022] Step 1: Mix bakuchiol, ceramide NP, and lecithin to obtain the first mixture; add hexyldecanol to the first mixture, heat to 50-85°C, and stir for 25-35 minutes to obtain oil phase A;

[0023] In the second step, under the condition of ultrasonic power of 300-800W, frequency of 20-60KHz, and water bath temperature of 50-85°C, ultrasonically dissolve oil phase A...

Embodiment 2

[0031] Example 2. A flexible liposome with high ceramide loading, comprising the following components by weight: bakuchiol, 2g; ceramide NP, 8g; lecithin, 8g; hexyldecanol, 30g; dipotassium glycyrrhizinate, 1g ; Water, 51 g.

[0032] A method for preparing flexible liposomes with a high ceramide loading capacity, comprising the following steps:

[0033] Step 1: Mix bakuchiol, ceramide NP, and lecithin to obtain the first mixture; add hexyldecanol to the first mixture, heat to 75°C, and stir for 30 minutes to obtain oil phase A;

[0034] In the second step, under the condition of ultrasonic power of 500W, frequency of 45KHz, and water bath temperature of 75°C, the oil phase A was ultrasonically dissolved for 30 minutes to obtain the oil phase B;

[0035] Step 3: Mix dipotassium glycyrrhizinate with water, heat to 75°C, stir for 20 minutes to dissolve, and obtain an aqueous phase;

[0036] Step 4: Add the oil phase B into the water phase and stir for 20 minutes to obtain a pr...

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Abstract

The invention discloses a flexible liposome with high ceramide loading capacity. The flexible liposome comprises: 2 parts of bakuchiol; 8 parts of ceramide NP; 8 parts of lecithin; 30 parts of hexyldecanol; 1 part of dipotassium glycyrrhizinate; and 51 parts of water. A preparation method of the flexible liposome comprises the following steps: mixing the bakuchiol, ceramide NP and lecithin; adding hexyldecanol into the oil phase A, heating to 50-85 DEG C, and stirring for 30 min to obtain an oil phase A; under the conditions that the ultrasonic power is 500 W, the frequency is 45 KHz and the water bath temperature is 50-85 DEG C, carrying out ultrasonic dissolution on the oil phase A for 30 min to obtain an oil phase B; mixing dipotassium glycyrrhizinate with water, heating to 50-80 DEG C, and stirring for 20 min for dissolving to obtain a water phase; adding the oil phase B into the water phase, and stirring for 20 min to obtain a primary mixed solution; and carrying out homogenization circulation on the preliminary mixed solution for 5 times by using a high-pressure homogenizer under the condition of 800 bar, so as to obtain the flexible liposome with high ceramide loading capacity. The flexible liposome has the characteristics that the stability of the ceramide can be effectively improved, and the utilization rate of the ceramide is increased.

Description

technical field [0001] The invention relates to a ceramide liposome, in particular to a flexible liposome with high ceramide loading capacity and a preparation method thereof. Background technique [0002] Located on the surface of the body, the skin is one of the largest and most important organs of the human body, and it is also the first line of physiological defense of the human body. As the outermost organ of the human body, the skin prevents the penetration of harmful substances and retains moisture in the body. The stratum corneum (SC) is located in the outermost layer of the skin, about 5-8 μm, composed of 10-15 layers of lifeless flat keratinocytes, and is the first protective barrier of the skin. The structure of the stratum corneum is usually expressed as a "brick and mud structure". The horny cells are long, flat and tile-shaped. They are the main cell components of the stratum corneum and act as "bricks". They are composed of ceramide, cholesterol and fatty aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/68A61K8/14A61K8/34A61K8/63A61Q19/08A61Q19/00
CPCA61K8/68A61K8/14A61K8/347A61K8/63A61Q19/08A61Q19/00A61K2800/82A61K2800/592
Inventor 张大勇毕永贤杜雨涵李昊周浩淼胡雪情唐萌孔德承
Owner ZHEJIANG YIGE ENTERPRISE MANAGEMENT GRP CO LTD
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