Medicine release-controlled microcapsule with dual-layer membrane and its preparing process

A drug controlled release and microcapsule technology, which is applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of inconsistent microcapsule film strength and controlled release performance, and achieve the advantages of intestinal drug delivery, rich content, Effect of good bioadhesion

Inactive Publication Date: 2004-03-03
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the existing literature reports, there are certain problems in the selection of materials, preparation routes and process conditions of ACA microcapsules, and the contradiction between the strength of the microcapsule membrane and the controlled release performance cannot be solved.

Method used

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  • Medicine release-controlled microcapsule with dual-layer membrane and its preparing process
  • Medicine release-controlled microcapsule with dual-layer membrane and its preparing process
  • Medicine release-controlled microcapsule with dual-layer membrane and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 bilayer film structure ACA microcapsule

[0027] Under the condition of 20°C, according to the volume ratio of calcium alginate and chitosan solution of 1:2, the film-forming reaction was carried out for 25 minutes, and then the surface of the beads was covered with 2.5 volumes of sodium alginate solution with a concentration of 0.2%, and then combined with chitosan The sugar solution was subjected to the second film-forming reaction for 20 minutes. Chitosan solution concentration: 0.2%, chitosan molecular weight: 70,000 for the first time, 200,000 for the second time, and deacetylation degree: 85%. ACA microcapsules with double-layer membrane structure ( figure 1 ).

Embodiment 2

[0028] Embodiment 2 application test (1)

[0029] The double-layer membrane structure microcapsules prepared in Example 1 were not damaged during the release process of the simulated gastrointestinal fluid. The microcapsules were administered to mice, and no capsules were found in the small intestine of the mice for 48 hours.

Embodiment 3

[0030] Embodiment 3 application test (II)

[0031] After the microencapsulated bovine hemoglobin prepared by the method of Example 1 was released in simulated gastrointestinal fluid for 7 hours, there was still a large amount of unreleased protein in the microcapsules ( figure 2 ).

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Abstract

A release controlled sodium algate / chatosan microcapsule with dual-layer film structure for medicine is prepared through two film-foring reactions. It has better biological compatibility, degradability and film-forming nature, and low cost.

Description

technical field [0001] The invention relates to a double-layer film drug controlled release microcapsule and a preparation method thereof. Background technique [0002] Controlled release technology is a technology that slowly releases chemical substances or biochemical substances to achieve effective utilization and reduce toxic and side effects. It has shown broad application prospects in the fields of medicine, pesticides, fertilizers, and daily chemicals. Among them, microencapsulation technology has always been the main direction of research on controlled release carriers, especially in the field of drug controlled release, which has shown excellent performance. The development of recombinant DNA technology enables large-scale production of genetically engineered peptide and protein drugs and is widely used in clinical practice, playing a pivotal role in the treatment of many major diseases. For example, interleukin-2 for the treatment of tumors, interferon for the tre...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/62
Inventor 刘群马小军
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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