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LPL new site mutant gene of hyperlipidemia accompanied by recurrent acute pancreatitis and application of LPL new site mutant gene

A technology for acute pancreatitis and site mutation, which can be used in applications, genetic engineering, plant genetic improvement, etc., and can solve problems such as unknown pathogenic gene loci

Inactive Publication Date: 2022-02-08
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Although the above-mentioned existing studies have clearly described the pathogenic mechanism of HTG, there are still unknown pathogenic gene loci

Method used

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  • LPL new site mutant gene of hyperlipidemia accompanied by recurrent acute pancreatitis and application of LPL new site mutant gene
  • LPL new site mutant gene of hyperlipidemia accompanied by recurrent acute pancreatitis and application of LPL new site mutant gene
  • LPL new site mutant gene of hyperlipidemia accompanied by recurrent acute pancreatitis and application of LPL new site mutant gene

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Embodiment Construction

[0034] Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with the drawings are exemplary, and are only used to explain the present invention, but not to be construed as limiting the present invention.

[0035] Those skilled in the art can understand that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0036] It should also be understood that terms such as those defined in commonly used dictionaries should be understood to have a meaning consistent with the meaning in the context of the prior art, and will not be interpreted in an idealized or overly formal sense unless defined as her...

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Abstract

The invention provides an LPL new site mutant gene for hyperlipidemia accompanied by recurrent acute pancreatitis and application, and belongs to the technical field of biological medicine. The nucleotide sequence of the LPL mutant gene is that the 986 site of the nucleotide sequence of a wild-type LPL protein gene is mutated from A to C, and the sequence of the wild-type LPL protein gene is as shown in SEQ No.1. The LPL mutant polypeptide encoded by the LPL mutant gene is a kit for detecting the hypertriglyceridemia or acute pancreatitis LPL mutant gene by replacing tyrosine at the 329 site of an amino acid sequence which is encoded by a wild type LPL protein gene and is shown as SEQ No.2 with serine. The invention provides a novel separated LPL mutant gene for familial hypertriglyceridemia or acute pancreatitis, further explains a mechanism of enzyme activity reduction caused by LPL mutation, and provides a sufficient basis for treatment effect and dynamic observation of familial hypertriglyceridemia or acute pancreatitis.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a LPL new site mutation gene and application of hyperlipidemia accompanied by recurrent acute pancreatitis. Background technique [0002] Lipids specifically cover lipids and fats. Fat refers to triglycerides of fatty acids, that is, triglycerides (TG), which are the result of esterification of three hydroxyl groups inside glycerol molecules by fatty acids. TG is a very key organic compound in the human body, mainly manifested in: the most important source of human energy, is the main component of glycolipids and biofilms --- an important part of phospholipids, and plays a role in the body's material metabolism. The liver is the place with the strongest ability to synthesize triglycerides, and the small intestine and adipose tissue are also important places for the synthesis of triglycerides. The triglycerides stored in adipocytes are usually hydrolyzed by fat mobilization, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/55C12N9/20C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156G01N33/6893G01N33/573G01N2333/916G01N2800/067Y02A50/30
Inventor 陈丽侯新国蒋玲刘福强孙玉静张晓黎王川
Owner SHANDONG UNIV QILU HOSPITAL
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