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Noninvasive blood glucose testing method based on water peak blood glucose correction

A blood sugar and water peak technology, applied in diagnostic recording/measurement, medical science, diagnosis, etc., can solve the problems of inability to eliminate fluorescence interference, affect the final effect, inability to take into account the normalization of water peaks and the elimination of fluorescence influence, etc. Interference, improve test accuracy, eliminate the effect of fluorescent bleaching

Active Publication Date: 2022-01-28
广西澍源智能科技有限公司 +1
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Problems solved by technology

However, normalization of water peaks cannot eliminate fluorescence interference, which will affect the final effect, and cannot take into account both normalization of water peaks and elimination of fluorescence effects

Method used

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  • Noninvasive blood glucose testing method based on water peak blood glucose correction
  • Noninvasive blood glucose testing method based on water peak blood glucose correction
  • Noninvasive blood glucose testing method based on water peak blood glucose correction

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Embodiment Construction

[0029] An exemplary embodiment of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present disclosure are shown, it is understood that the disclosure can be implemented in various forms without limitation. Instead, these embodiments are provided to be more thoroughly understood to disclose the present disclosure, and can communicate the scope of the scope of the present disclosure to those skilled in the art.

[0030] The proposed principles of the present invention will be described below.

[0031] The principle of Raman spectroscopy is to illuminate samples by a single wavelength of excitation light, and the sample produces a series of Raman spectroscopy of other wavelengths, which is called Raman displacement, and different Raman displacements correspond to different substances. Raman displacement unit is cm -1 . Most substances (including glucose) Raman spectroscopy is located i...

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Abstract

The invention discloses a noninvasive blood glucose testing method based on water peak blood glucose correction. The method comprises the following steps: collecting a Raman spectrum and a blood glucose concentration value of a sample, and establishing a partial least square method model; carrying out overall normalization on the collected spectrum; selecting a water characteristic peak which is not overlapped with other substance peaks in the Raman spectrum of the sample, and calculating the area of the water characteristic peak; obtaining the blood sugar water peak product according to the water characteristic peak area and the corresponding blood sugar value; solving a correlation curve based on a partial least square method model according to the normalized Raman spectrum and the blood sugar water peak product; similarly, obtaining the Raman spectrum of the to-be-detected sample, and carrying out overall normalization on the Raman spectrum; and dividing the water characteristic peak area in the spectrum by the blood sugar water peak product corresponding to the normalized Raman spectrum obtained according to the correlation curve to obtain the concentration value of the blood sugar to be detected. Various interference factors are effectively eliminated through Raman spectrum overall normalization and water characteristic peak blood glucose correction, and the Raman spectrum blood glucose testing precision is improved.

Description

Technical field [0001] The present invention relates to the field of non-invasive blood sugar detection, in particular, refers to a non-invasive blood glucose test method based on water peak blood sugar correction. Background technique [0002] Diabetes is a common metabolic endocrine disease, with high blood sugar as main characteristics, in recent years, there have been significant rising trends in recent years, and Chinese diabetes patients ranks first in the world. The current treatment in diabetic patients is mainly regulated for glucose metabolism in patients. It is important in clinical treatment to determine the amount of medication by the high and low of the blood of the patient. Therefore, blood glucose monitoring is tracked, evaluating diabetes control and efficacy is very important. [0003] Non-invasive blood sugar measurement technology has become a study focus on the patient's body due to the need for blood collection and damage to the patient's body. Non-invasive ...

Claims

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Application Information

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IPC IPC(8): A61B5/1455A61B5/00
CPCA61B5/14532A61B5/7203A61B5/14551A61B2560/0233
Inventor 周淼淼聂荣志钟文婷彭波储涛熊泉赵子健张广维
Owner 广西澍源智能科技有限公司
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