Preparation method and application of bionic nano-drug targeting hepatic stellate cells

Abstract

The invention relates to a preparation method and application of a bionic nano-drug for targeting hepatic stellate cells, which can effectively solve the problem that the synthesis is relatively tedious because the surface of a nano-drug is modified with a targeting ligand by a chemical modification method in the conventional nano-carrier for targeting hepatic stellate cells. According to the technical scheme for solving the problems, by using the homologous targeting function of the hepatic stellate cells, the hydrophobic small molecule drug BAY 11-7082 for inducing the apoptosis of the hepatic stellate cells (HSCs) is wrapped, and the nano-drug with the hepatic stellate cell targeting is obtained through the ultrasonic co-extrusion method, and the bionic nano-drug can induce the apoptosis of the hepatic stellate cells, reduce the collagen secretion, and can achieve the anti-hepatic fibrosis purpose by relieving inflammation microenvironment; and the preparation method provided by the invention is simple and convenient, has good biocompatibility, and is an innovation of bionic nano-drugs.

Description

technical field [0001] The invention relates to the field of nano drug preparations, in particular to a preparation method and application of a bionic nano drug targeting hepatic stellate cells. Background technique [0002] Hepatic fibrosis is a process of continuous liver repair resulting from long-term chronic liver injury, characterized by excessive deposition of extracellular matrix (ECM) from various etiologies, including bile acid stasis, viral infection, alcoholic liver disease, and nonalcoholic Steatohepatitis, etc. Liver fibrosis is a highly dynamic and reversible process with greater plasticity than any other type of organ fibrosis. Various drugs such as small molecules, proteins, siRNA, miRNA and plasmids have been used for anti-fibrotic therapy. However, effective anti-fibrosis therapy has not been provided so far, and no anti-hepatic fibrosis drug has been approved. Hepatic stellate cells (HSCs) play a key role in the pathological development of liver fibros...

AI Technical Summary

Problems solved by technology

[0004] In view of the above situation, in order to solve the defects of the prior art, the object of the present invention is to provide a preparation method and application of a biomimetic nanomedicine targeting hepatic stellate cells, which can effectively solve the problem of the current nanocarriers targeting hepatic stellate cells. Usually, the targeting ligand is modified on the surface of nano-drugs by chemical modification, and the synthesis is relatively cumbersome.

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