Inosine injection with remarkable intravenous injection effect and preparation method of inosine injection

A technology of injection and inosine, which is applied in the field of medicine, can solve the problems of venous blood vessel irritation, achieve the effects of reducing blood vessel irritation, relieving nausea, and preventing oxidative deterioration

Pending Publication Date: 2022-01-11
SHANDONG WEIFANG PHARMA FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of inosine injection with remarkable intravenous injection effect and its preparation method, to solve the problem that the venous blood vessels are stimulated to a certain extent in the above-mentioned background technology

Method used

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  • Inosine injection with remarkable intravenous injection effect and preparation method of inosine injection
  • Inosine injection with remarkable intravenous injection effect and preparation method of inosine injection

Examples

Experimental program
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Effect test

Embodiment 1

[0022] An inosine injection for intravenous infusion is composed of the following raw materials in parts by weight: 0.2 g of inosine, 0.1 g of propylene glycol, 0.1 g of sodium hydroxide, and 0.1 g of anhydrous sodium sulfite.

[0023] A method for preparing inosine injection for intravenous infusion, comprising the following steps:

[0024] Step 1: Introduce carbon dioxide into the reaction tank to saturation, and add inosine and anhydrous sodium sulfite weighed according to the above weight parts into the reaction tank in sequence and stir, stir and dissolve, then add propylene glycol and sodium hydroxide to stir until dissolved, and coarsely filter the medicinal solution after stirring to obtain filtrate one;

[0025] Step 2: Add activated carbon for needles to the filtrate 1 in step 1, heat the filtrate 1 to 60-70°C, stir, add a pH regulator, adjust the pH value to 6-7, and then filter with a carbon removal filter Decarburization obtains filtrate two;

[0026] Step 3: Fi...

Embodiment 2

[0031] A kind of inosine injection with remarkable intravenous effect, the injection is made up of the following raw materials in parts by weight: inosine 0.3g, propylene glycol 0.3g, sodium hydroxide 0.2g, anhydrous sodium sulfite 0.2g

[0032] A kind of inosine injection with remarkable intravenous effect and preparation method thereof, comprising the following steps:

[0033] Step 1: Introduce carbon dioxide into the reaction tank to saturation, and add inosine and anhydrous sodium sulfite weighed according to the above weight parts into the reaction tank in sequence and stir, stir and dissolve, then add propylene glycol and sodium hydroxide to stir until dissolved, and coarsely filter the medicinal solution after stirring to obtain filtrate one;

[0034] Step 2: Add activated carbon for needles to the filtrate 1 in step 1, heat the filtrate 1 to 60-70°C, stir, add a pH regulator, adjust the pH value to 6-7, and then filter with a carbon removal filter Decarburization obta...

Embodiment 3

[0040] An inosine injection with remarkable intravenous effect, the injection is composed of the following raw materials in parts by weight: 0.4 g of inosine, 0.2 g of propylene glycol, 0.3 g of sodium hydroxide, and 0.2 g of anhydrous sodium sulfite.

[0041] A kind of inosine injection with remarkable intravenous effect and preparation method thereof, comprising the following steps:

[0042] Step 1: Introduce carbon dioxide into the reaction tank to saturation, and add inosine and anhydrous sodium sulfite weighed according to the above weight parts into the reaction tank in sequence and stir, stir and dissolve, then add propylene glycol and sodium hydroxide to stir until dissolved, and coarsely filter the medicinal solution after stirring to obtain filtrate one;

[0043] Step 2: Add activated carbon for needles to the filtrate 1 in step 1, heat the filtrate 1 to 60-70°C, stir, add a pH regulator, adjust the pH value to 6-7, and then filter with a carbon removal filter Decar...

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Abstract

The invention belongs to the technical field of medicines, and particularly discloses inosine injection with a remarkable intravenous injection effect and a preparation method of the inosine injection. The injection is prepared from the following raw materials in parts by weight: inosine, propylene glycol, sodium hydroxide and anhydrous sodium sulfite. The inosine injection can effectively relieve the adverse reactions of nausea and vomiting generated when the injection is used for relieving intravenous drip, meanwhile, the stimulation to blood vessels is reduced, the inosine injection can be used for rescuing and treating the pulmonary heart disease in an intravenous injection manner, and a drug approval process and clinical application both focus on 'intravenous injection' and the remarkable 'intravenous injection' effect as the core; the injection can be prevented from being oxidized through anhydrous sodium sulfite, besides, the injection is prepared through reaction under the protection of carbon dioxide gas, the contamination risk can be effectively reduced, and besides, the problem of oxidative deterioration can be effectively prevented by filling nitrogen when the injection is filled, and the stability and the safety of the injection are ensured.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an inosine injection with remarkable intravenous injection effect and a preparation method thereof. Background technique [0002] Inosine (Inoside) is also called hypoxanthine nucleoside. Because it can participate in energy metabolism and protein synthesis in the body, activate pyruvate oxidase, make cells continue to metabolize under hypoxic conditions, and promote rapid repair of damaged liver cells and cardiomyocytes, so it is widely used clinically. It is used in the treatment of diseases such as leukopenia and thrombocytopenia, various acute and chronic hepatitis, heart disease, central retinitis, and optic atrophy. Intravenous infusion may cause nausea, facial flushing and other adverse reactions, and it may stimulate veins to a certain extent. Inosine injection has been included in the Chinese Pharmacopoeia, and it is usually a colorless or almost colorless clear liquid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/02A61K47/04A61K31/7076A61P9/00A61P11/00
CPCA61K9/08A61K9/0019A61K47/02A61K31/7076A61P9/00A61P11/00
Inventor 李欢
Owner SHANDONG WEIFANG PHARMA FACTORY
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