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A kind of combined medicine and use

A technology of drugs and uses, applied in the field of combined drugs and uses, can solve problems such as sexual dysfunction, achieve the effect of inhibiting the increase of volume, improving tissue lesions, and having a good clinical application prospect

Active Publication Date: 2022-08-05
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the common clinical BPH drugs include 5α-reductase inhibitors, α-receptor blockers, etc. These two types of drugs are often used in combination to treat benign prostatic hyperplasia and concurrent lower urinary tract symptoms. While relieving the symptoms of BPH, these drugs often cause various adverse reactions such as sexual dysfunction, dizziness, hypotension, etc.

Method used

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  • A kind of combined medicine and use
  • A kind of combined medicine and use
  • A kind of combined medicine and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 The improvement effect of combined drugs on benign prostatic hyperplasia and lower urinary tract symptoms

[0036] Preparation of Cynomorium extract: take 3kg Cynomorium decoction pieces, add 24L of 60% ethanol solution to heat and reflux for extraction twice, 2h each time, after the extract is evaporated in a rotary evaporator, freeze-dried in a freeze dryer to obtain Cynomorium Extract;

[0037] Preparation of Phellodendron Phellodendri extract: take 3kg of Phellodendron Phellodendri decoction pieces, add 30L of 60% ethanol solution, heat and pressurize for 2 times, 2 hours each time, combine the extracts, filter, depressurize distillation into extract, and vacuum dry to obtain Phellodendron Phellodendri Extract thing.

[0038] 108 specific pathogen-free (SPF grade) male Wistar rats, weighing 230-250 g, were acclimated for one week and then castrated. Twelve rats were randomly selected and subjected to sham operation. The scrotal skin, capsule tissue and c...

Embodiment 2

[0047] Example 2 Combination of drugs on E in rat serum 2 , T, E 2 Influence of / T, DHT

[0048] The inventor's research found that there is an imbalance of estrogen and androgen levels in patients with benign prostatic hyperplasia and lower urinary tract symptoms, especially clinically, E. 2 / T is one of the efficacy indicators for the treatment of benign prostatic hyperplasia and lower urinary tract symptoms. It is generally considered that E 2 The lower the value of / T, the better the effect of drug treatment. The application of the present application to the serum estradiol (E 2 ), testosterone (T), estradiol / testosterone (E 2 / T) and the content of dihydrotestosterone (DHT) were detected, so as to verify the therapeutic effect of the combination drug of the present application on benign prostatic hyperplasia and lower urinary tract symptoms.

[0049] In Example 1, blood was collected from the abdominal aorta of each group of rats after administration, and the superna...

Embodiment 3

[0051] Example 3 The effect of combined drugs on the maximum voiding pressure in rats

[0052] In Example 1, bladder perfusion was performed to detect urination parameters in each group of rats, and the detection results of the maximum voiding pressure (MVP) of each group of rats were as follows Figure 9 The bladder perfusion is to inject anesthesia into the abdominal cavity of the rats in each group, fix them in the supine position, and press the lower abdomen of the rats to discharge the remaining urine from the bladder; open the abdominal cavity to separate and cut the ureter, and ligate the ureter near the bladder; the venous needle is inserted from the top of the bladder, The other side of the venous needle is connected with a hose and a micro-perfusion pump, and the signal is collected and recorded by a four-channel pressure sensor PowerLab8 / 30. The background level of intravesical pressure in rats was set to zero before the experiment. The bladder was perfused with 0....

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Abstract

The application provides a combination medicine, which comprises Cynomorium extract and Phellodendron chinensis extract, and the weight ratio of a single administration of the Cynomorium extract to the single administration of the Phellodendron Phellodendri extract is 1:(1.0-1.5) . The application also provides the use of the combined medicament in the preparation of a medicament for preventing and / or treating benign prostatic hyperplasia and lower urinary tract symptoms. The combination drug provided by the application can inhibit the enlargement of the prostate volume, reduce the prostate index and bladder index, improve the tissue lesions of the prostate and bladder, reduce the level of estradiol / testosterone, reduce the maximum voiding pressure, and increase the detrusor muscle. The muscle tension can be used to prevent and / or treat benign prostatic hyperplasia and lower urinary tract symptoms, and then be used to prepare a medicament for preventing and / or treating benign prostatic hyperplasia and lower urinary tract symptoms. The combined medicament of the present application has a synergistic effect, is suitable for long-term treatment, and has a good clinical application prospect.

Description

technical field [0001] The present application relates to the field of medical technology, in particular to a combination drug and its use. Background technique [0002] Benign prostatic hyperplasia (BPH) is a high incidence of urinary system in middle-aged and elderly men, and is closely related to age. Epidemiological studies have shown that 50% of men over the age of 60 can observe BPH symptoms at the tissue level; the prevalence of BPH in men over the age of 80 is close to 90%. As the size of the prostate continues to increase, it will compress the bladder neck and narrow the urethra, eventually leading to lower urinary tract symptoms such as urinary frequency, urgency, incomplete urination, and bladder outlet obstruction to varying degrees (Lower Urinary Tract symptoms, LUTs), in severe cases, bilateral upper urinary tract hydrops can occur and lead to renal insufficiency. If the treatment is not timely, it can easily lead to serious complications such as hematuria, ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61P13/08A61P13/02A61P13/10
CPCA61K36/185A61K36/756A61P13/08A61P13/02A61P13/10A61K2300/00
Inventor 苗琳高秀梅刘二伟王亚静常艳旭马亚宣吴垚锌
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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