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Application of isoquercetin in treatment of steatohepatitis

A steatohepatitis and isoquercetin technology, applied in the field of medicine, can solve problems such as no application reports, achieve remarkable medicinal effects, be suitable for widespread application, and improve the effect of liver lipid accumulation

Pending Publication Date: 2021-12-07
SHANDONG RUIYING PIONEER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that isoquercetin has a wide range of pharmacological effects such as anti-inflammation, anti-oxidation, antihypertensive, and anti-depression, but so far there has been no report on the application of this compound in the preparation of anti-steatohepatitis therapeutic drugs

Method used

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  • Application of isoquercetin in treatment of steatohepatitis
  • Application of isoquercetin in treatment of steatohepatitis
  • Application of isoquercetin in treatment of steatohepatitis

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Embodiment Construction

[0018] The technical solution of the present invention will be described in detail below in conjunction with specific examples, so as to facilitate the understanding of the present invention, but not to limit the present invention.

[0019] The invention discloses the application of isoquercetin in treating steatohepatitis. The general structural formula of the isoquercetin is:

[0020] .

[0021] The following are the results of the pharmacodynamic test of isoquercetin:

[0022] 1. In vivo effect of isoquercetin on rat steatohepatitis induced by high-fat diet

[0023] Hyperlipidemia models have been used to simulate changes in lipid metabolism in humans with metabolic syndrome. Hepatic lipid metabolism disorder is the central link of various metabolic diseases. Animal models of hyperlipidemia to study disturbances in hepatic lipid metabolism, which are associated with inflammatory responses. Studies have shown that systemic and local inflammatory responses can aggravate...

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Abstract

The invention relates to the technical field of medicines, and particularly discloses application of isoquercetin in treatment of steatohepatitis. The invention discloses application of the isoquercetin in treatment of the steatohepatitis, the isoquercetin can significantly improve liver lipid accumulation, liver inflammation, liver oxidative stress and liver injury levels caused by HFD, has a significant medicinal effect, and is suitable for wide popularization and application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an application of isoquercetin in the treatment of steatohepatitis. Background technique [0002] Non-alcoholic steatohepatitis (NASH) is also known as metabolic Steatohepatitis is a malignant progressive stage of non-alcoholic fatty liver disease, and severe cases can develop into liver fibrosis. The main feature of NASH is bullous steatosis of liver cells accompanied by liver cell damage and inflammation. If NASH is not controlled at this stage, after the damaged liver cells die, the liver will start its own damage repair mechanism to supplement the dead cells. fibrosis is a physiological response accompanying the repair process of liver damage. Liver metabolic toxicity caused by chronic inflammation and excessive load will continue to lead to liver cell death, and the process of liver fibrosis will always exist and accumulate, and the accumulated liver fibrosis will eventua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16
CPCA61K31/7048A61P1/16
Inventor 尚靖彭继先马佶李茂如王涛杨林青周汝德
Owner SHANDONG RUIYING PIONEER PHARMA
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