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Whitening composition aiming at sensitive skin and application thereof

A sensitive skin and whitening technology, applied in the field of skin care products, can solve problems such as poor use effect, high irritation, and poor product stability, and achieve good whitening effect, high safety, and the effect of inhibiting inflammatory reactions

Pending Publication Date: 2021-11-16
湖南冰溪生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there are many skin care products claiming to have whitening effect on the market, most of which achieve the whitening effect by inhibiting the formation of melanin, but the whitening effect needs to be further improved, and the product has poor stability and strong irritation
Especially for people with sensitive skin, there are relatively few skin care products for improving dull and yellowish skin, which are not effective and irritating

Method used

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  • Whitening composition aiming at sensitive skin and application thereof
  • Whitening composition aiming at sensitive skin and application thereof
  • Whitening composition aiming at sensitive skin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0037] According to the formula in Table 1, prepare the whitening composition product respectively:

[0038] Heat water, butylene glycol, p-hydroxyacetophenone, and 1,2-hexanediol to mix and dissolve in advance, heat to 80-85°C, then add tranexamic acid, EDTA.2Na, and hydroxyethylpiperazineethane in sequence Sulfonic acid, after stirring evenly, add carnosine when the temperature drops to 60°C, add Magnolia extract, bis-diethoxydiethylene glycol cyclohexane 1,4-dicarboxylate when the temperature drops to 45-50°C Ester, nonapeptide-1, and sodium bisulfite were stirred evenly to obtain a whitening composition product. The pH of the whitening composition is 6.0-6.8, and the appearance of the product is a colorless transparent liquid.

[0039] The specific proportions and pH values ​​of each formula are as follows. Examples 1-4 correspond to groups 1-4 in turn, and CK is the formula without the whitening active ingredient.

[0040] The prescription (unit: wt%) of table 1 embodim...

Embodiment 5

[0045] Experiment 1. Stability verification

[0046] Put the composition products made by groups 1-5 and CK in the present invention under the conditions of room temperature, refrigerator (-10°C) and oven (45°C) respectively, according to 0 day, 3 days, 7 days, 15 days, Stability inspection was carried out in 30 days to observe whether the products of each composition had precipitation and delamination.

[0047] The result is as follows:

[0048] Table 3 Stability test results

[0049]

[0050] The results showed that the stability of the products of each group of compositions was good (normal: no precipitation and delamination).

[0051] Experiment 2. Sensitive skin tolerance efficacy test

Embodiment 3

[0052] Get embodiment 3 and carry out sensitive skin tolerance efficacy test;

[0053] Experimental population: 120 subjects, all of whom are female aged 20-50, in good health, without taking drugs, and in line with the voluntary selection criteria for subjects.

[0054] Test method: A dermatologist conducts a clinical assessment of the subject's facial skin to determine that the subject has sensitive skin. The subject applies the composition product to the cheeks once a day in the morning and evening (each application is about 0.5 drops of 10 drops). ml), when the subject applied the composition product on the 3rd day and the 7th day, observe and record the tolerance of the cheek skin of the subject.

[0055] Clinical Observation Index

[0056] Clinicians evaluated the observation indicators before treatment, on the 3rd day and 7th day after treatment. Evaluation content of objective indicators: erythema, desquamation, evaluation content of subjective indicators: dryness, i...

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Abstract

The invention relates to the field of skin care products, in particular to a whitening composition aiming at sensitive skin and application thereof. The composition comprises tranexamic acid, carnosine, nonapeptide-1, magnolia sieboldii extract and hydroxyethyl piperazine ethanesulfonic acid; the mass ratio of tranexamic acid to carnosine to nonapeptide-1 to magnolia sieboldii extract to hydroxyethyl piperazine ethanesulfonic acid is (1-5): (0.1-1): (1-2): (0.5-2): (1-5). Experiments show that the whitening composition and the application product have a better whitening effect, are high in safety, have the effects of inhibiting inflammatory response and relieving sensitive skin, and are particularly suitable for people with sensitive skin.

Description

technical field [0001] The present application relates to the technical field of skin care products, in particular to a whitening composition for sensitive skin and its application. Background technique [0002] At present, there are many skin care products claiming to have whitening effect on the market, most of which achieve the whitening effect by inhibiting the formation of melanin, but the whitening effect needs to be further improved, and the product is poor in stability and irritating. In particular, there are relatively few skin care products for people with sensitive skin to improve dull and yellowish skin, which are not effective and irritating. [0003] The effect or irritation of skin whitening products is closely related to the compatibility of the formula. Therefore, low-irritation or non-irritant whitening skin care products suitable for sensitive skin have always been the constant pursuit of medical cosmetologists. Therefore, it is necessary to develop a wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/64A61K8/49A61K8/44A61K8/37A61Q19/02A61Q19/00A61P29/00
CPCA61K8/9789A61K8/64A61K8/4946A61K8/494A61K8/44A61K8/375A61Q19/02A61Q19/005A61P29/00A61K2800/782A61K2800/592
Inventor 李吉谢红付王乾
Owner 湖南冰溪生物科技有限公司
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