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Preparation method of continuous adhesion hydrogel, hydrogel obtained by preparation method and application of hydrogel

A hydrogel, persistent technology, applied in application, surgery, drug delivery, etc., can solve the problem of poor adhesion persistence and durability of hydrogel, limit the continuous application of hydrogel, unstable long-term adhesion and other problems, to achieve rapid high-strength adhesion and repeatable adhesion, improve underwater adhesion ability, and simple and rapid preparation process

Active Publication Date: 2021-11-12
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the biphenyl structure constructed by tannic acid has better adhesion performance, for the hydrogel in the physiological environment for a long time, due to the lack of polymer interfacial anchoring effect with the matrix surface, or in wet Under the action of the environmental hydration layer, the interfacial interaction is destroyed, so that the hydrogel exhibits poor adhesion persistence and persistence; in addition, in the existing PAAc / CS / TA-based hydrogel, the use of trivalent cations (such as Fe 3+ , Al 3+ ) for further cross-linking to obtain more excellent mechanical properties and adhesive strength, although trivalent cations can chelate with the carboxyl group of PAAc and the pyrogallol group of TA to form an ionic bond
However, such interactions have the possibility of ion displacement in saline solution, resulting in unstable long-term adhesion energy, limiting the sustained application of hydrogels in physiological environments.

Method used

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  • Preparation method of continuous adhesion hydrogel, hydrogel obtained by preparation method and application of hydrogel
  • Preparation method of continuous adhesion hydrogel, hydrogel obtained by preparation method and application of hydrogel
  • Preparation method of continuous adhesion hydrogel, hydrogel obtained by preparation method and application of hydrogel

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Experimental program
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Effect test

Embodiment 1

[0034] (1) Dissolve 20 mg N, N'-methylenebisacrylamide in 1 mL deionized water to prepare a crosslinker solution; dissolve 0.4 g ammonium persulfate in 1 mL deionized water to prepare an initiator solution ;

[0035] (2) Dissolve 3 mL of acrylic acid, 0.3 g of chitosan, and 200 μL of cross-linking agent solution in 10 mL of deionized water, and stir well;

[0036] (3) 0.3 g of tannic acid was dissolved in the solution of step (2), and stirred thoroughly for 10 min to form a precursor solution of the hydrogel matrix;

[0037] (4) Place the precursor solution of the hydrogel matrix in a 50 °C water bath and incubate for 30 min with stirring, add 200 μL of the initiator solution drop by drop, stir quickly and then pour it into the mold, and let it stand at 60 °C to react and form a hydrogel Gel base.

[0038] The repeated adhesion behavior of the hydrogel matrix prepared in the present invention to pigskin was evaluated according to the ASTM F2258 tensile test. figure 1 It was...

Embodiment 2

[0040] (1) Dissolve 20 mg N, N'-methylenebisacrylamide in 1 mL deionized water to prepare a crosslinker solution; dissolve 0.4 g ammonium persulfate in 1 mL deionized water to prepare an initiator solution ;

[0041] (2) Dissolve 3 mL of acrylic acid, 0.3 g of chitosan, and 300 μL of cross-linking agent solution in 10 mL of deionized water, and stir well;

[0042] (3) 0.3 g of tannic acid was dissolved in the solution of step (2), and stirred thoroughly for 10 min to form a precursor solution of the hydrogel matrix;

[0043] (4) Place the precursor solution of the hydrogel matrix in a 50 °C water bath and incubate for 30 min with stirring, add 200 μL of the initiator solution drop by drop, stir quickly and then pour it into the mold, and let it stand at 60 °C to react and form a hydrogel Gel base.

[0044] According to the 180-degree peeling test, the interfacial toughness of the hydrogel matrix prepared in Example 2 of the present invention adhered to different engineering ...

Embodiment 3

[0046] (1) Dissolve 20 mg N, N'-methylenebisacrylamide in 1 mL deionized water to prepare a crosslinker solution; dissolve 0.4 g ammonium persulfate in 1 mL deionized water to prepare an initiator solution ;

[0047] (2) Dissolve 3 mL of acrylic acid, 0.3 g of chitosan, and 300 μL of cross-linking agent solution in 10 mL of deionized water, and stir well;

[0048] (3) 0.3 g of tannic acid was dissolved in the solution of step (2), and stirred thoroughly for 10 min to form a precursor solution of the hydrogel matrix;

[0049] (4) Place the precursor solution of the hydrogel matrix in a 50 °C water bath and incubate for 30 min with stirring, add 200 μL of the initiator solution drop by drop, stir quickly and then pour it into the mold, and let it stand at 60 °C to react and form a hydrogel Gel matrix;

[0050] (5) Dissolve 1.9524 g of 4-morphineethanesulfonic acid (MES) in 100 mL of deionized water to make 0.1 mol / L MES buffer solution, and adjust the pH to 5 with 1 mol / L sodi...

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Abstract

The invention discloses a preparation method of continuous adhesion hydrogel, the hydrogel obtained by the preparation method and application of the hydrogel. According to the method, chemical-physical double-network cross-linked hydrogel is prepared from a blended solution with acrylic acid, chitosan and tannic acid as main components. The polymer with positive charges is bridged by using specific carboxyl on the surface of the tissue, and a hydrogel-tissue interface which is continuously adhered in a physiological environment is constructed on the surface of the hydrogel matrix through multiple bonding by using an amide synthesis principle. The preparation process is simple and convenient, easy to control and suitable for large-scale industrial production, the used raw materials are easy to obtain and low in price, and the hydrogel has the application potential of a medical adhesive due to high tissue bonding efficiency and long-term stable wet adhesive strength.

Description

technical field [0001] The invention belongs to a medical adhesive preparation and a preparation method thereof, in particular to a preparation method and application of a hydrogel suitable for continuous adhesion in a physiological environment. Background technique [0002] As a type of adhesive material with soft matter properties, hydrogel adhesives play a key role in a wide range of wet environment applications, including underwater industrial repair and mechanical movement, tissue adhesion and sealing in physiological environments, etc. . Hydrogel adhesives offer better modulus matching and transport properties to the substrate than adhesives that exhibit viscoelastic liquid behavior. Acrylic acid, which is rich in functional carboxyl groups and can serve as multiple binding sites, has been widely used in the field of industrial adhesives because of its strong adhesion. It is very attractive to choose acrylic acid as the main component of hydrogel. However, the underw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/02C08L5/08C08K5/1545A61L24/00A61L24/08
CPCC08J3/075A61L24/0031A61L24/08A61L2400/04C08J2333/02C08J2405/08C08J2305/08C08J2433/02C08K5/1545
Inventor 张天柱梁敏
Owner SOUTHEAST UNIV
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