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Preparation method of micromolecular oligosaccharide moisturizing gel

A wet gel and small molecule technology, applied in medical preparations containing active ingredients, skin care preparations, pharmaceutical formulations, etc., can solve the problems of insufficient bacterial viability and decrease, achieve transdermal and maintain skin micro Ecological, environmentally friendly, and excellent transdermal effects

Inactive Publication Date: 2021-11-05
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] A large number of studies have shown that trehalose can promote the beneficial proliferation of probiotics such as bifidobacteria. Even after 30 minutes in a complex in vivo environment, it can maintain a cell viability of about 20%. Under the same conditions, glucose or no other external sources may cause bacterial growth The survival rate is less than 10% or decreases exponentially and tends to zero
[0006] How to effectively combine the above two small molecule monomer compounds to obtain a cosmetic raw material with comprehensive skin care effects such as good moisture retention, excellent skin penetration and maintenance of skin microecology, has not been reported so far.

Method used

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  • Preparation method of micromolecular oligosaccharide moisturizing gel
  • Preparation method of micromolecular oligosaccharide moisturizing gel
  • Preparation method of micromolecular oligosaccharide moisturizing gel

Examples

Experimental program
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Effect test

Embodiment 1

[0021] A small molecule oligosaccharide moisturizing gel:

[0022] Mix the following components uniformly at 50°C: the mass percentage of carboxymethyl trehalose is 1 wt%; the mass percentage of trehalose is 1 wt%; the mass percentage of penetration enhancer is 3 wt%; the mass percentage of rheology modifier It is 0.5wt%, and the rest is made up with water.

[0023] The penetration enhancer is a homogeneous mixture of Tween 80, propylene glycol, and PEG400 in a mass ratio of 2:2:1; the rheology regulator is 0.5 wt% polyacrylate-13.

Embodiment 2

[0025] A small molecule oligosaccharide moisturizing gel:

[0026] Mix the following components uniformly at 50°C: the mass percent of carboxymethyl trehalose is 2wt%; the mass percent of trehalose is 1.5wt%; the mass percent of penetration enhancer is 4wt%; the mass percent of rheology modifier The percentage is 0.8wt%, and the rest is made up with water.

[0027] The penetration enhancer is a homogeneous mixture of Tween 80, propylene glycol and PEG400 at a ratio of 2:2:1; the rheology modifier is 0.8wt% polyacrylate-13.

Embodiment 3

[0029] A small molecule oligosaccharide moisturizing gel:

[0030] Mix the following components uniformly at 50°C: the mass percent of carboxymethyl trehalose is 3wt%; the mass percent of trehalose is 2wt%; the mass percent of penetration enhancer is 5wt%; the mass percent of rheology modifier It is 1wt%, and the rest is made up with water.

[0031] The penetration enhancer is a homogeneous mixture of Tween 80, propylene glycol, and PEG400 in a mass ratio of 2:2:1; the rheology regulator is 1 wt% polyacrylate-13.

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Abstract

The invention discloses a micromolecular oligosaccharide moisturizing gel. The micromolecular oligosaccharide moisturizing gel disclosed by the invention comprises the following components in percentage by weight: 1-3% of carboxymethyl trehalose, 1-2% of trehalose, 3-5% of a penetration enhancer, 0.5-1% of a rheology modifier and the balance of water. According to the invention, the gel prepared by combining a novel micromolecular biomass oligosaccharide humectant with natural prebiotics can effectively improve the transdermal absorption efficiency of active matters, the dry damage resistance of fibroblasts and the multiplication capacity of skin probiotics. The oligosaccharide compound provided by the invention can be used as a novel moisturizing raw material of cosmetics, and can achieve a skin care effect from three aspects of skin moisturizing, excellent skin permeability and skin micro-ecology maintenance.

Description

technical field [0001] The invention relates to a small molecule oligosaccharide moisturizing gel, which belongs to the technical field of cosmetics. Background technique [0002] For common moisturizers in cosmetics such as glycerin and hyaluronic acid, in terms of molecular weight, the molecular weight of hyaluronic acid for cosmetics is mainly concentrated in the range of 10kDa-1000kDa, which is much higher than the optimal molecular weight range for transdermal absorption (generally ≤500Da) , in terms of oil-water partition coefficient, the logP value of glycerol is -1.33, which is far less than the optimum range for transdermal absorption (0-1), while other emollients such as polyols, pseudo natural moisturizing factors, sugars etc. These moisturizing ingredients still have some deficiencies in the actual formula selection, for example, polyol moisturizers will be limited by the environment and aging, improper use concentration or in a dry environment will easily cause ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/60A61K8/49A61K8/34A61K8/86A61K8/81A61Q19/00
CPCA61K8/60A61K8/4993A61K8/345A61K8/86A61K8/8152A61Q19/00A61Q19/007A61K2800/30
Inventor 荣绍丰黄煜玲管世敏李茜茜蔡宝国
Owner SHANGHAI INST OF TECH
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