Peripheral nerve injury repairing system

Abstract

The invention discloses a peripheral nerve injury repair system, and belongs to the field of peripheral nerve injury repair. The peripheral nerve injury repairing system comprises nerve conduit preparation, nerve conduit carrying NGF-7S and nerve conduit carrying NGF-7S combined magnetic stimulation application. A triple-network micro-fluidic hydrogel nerve conduit composed of alginate / calcium ions, polyacrylamide and polypyrrole is loaded with NGF-7S, the conductive nerve conduit can be caused to generate variable electromotive force in a pulsed magnetic field generated by an 8-shaped coil, directional growth and migration of Schwann cells are helped, myelin sheath formation is promoted in a non-invasive mode, and the nerve conduit can be used for treating myelin sheath diseases. Growth and differentiation of nerve cells are jointly promoted through slow controlled release of the carried NGF-7S and endogenous secreted nerve growth factors (NGF) of Schwann cells, and nerve regeneration and functional recovery of sciatic nerve defect rats can be promoted through combination of nerve conduit carried NGF-7S and magnetic stimulation.

Description

technical field [0001] The invention belongs to the field of peripheral nerve injury repair, and in particular relates to a peripheral nerve injury repair system. Background technique [0002] Autologous nerve transplantation technology has fewer sources of grafts and complications such as secondary injury, neuroma, and neuralgia caused by material extraction. Therefore, in short-distance peripheral nerve defects, the guidelines recommend the use of nerve conduits for repair; at the same time, past studies have It was found that short-distance (<3cm) nerve defects can be repaired through materials such as hollow silicone tubes, but this repair is extremely slow; at the same time, Hirohisa et al. reported that about 10% of patients could not achieve meaningful neuropathy after nerve catheter therapy. Functional recovery, this value reached 26% in the study of Weber and his colleagues; it shows that there are still a large number of patients who cannot benefit from the exis...

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Problems solved by technology

[0002] Autologous nerve transplantation technology has fewer sources of grafts and complications such as secondary injury, neuroma, and neuralgia caused by material extraction. Therefore, in short-distance peripheral nerve defects, the guidelines recommend the use of nerve conduits for repair; at the same time, past studies have It was found that short-distance (<3cm) nerve defects can be repaired through materials such as hollow silicone tubes, but this repair is extremely slow; at the same time, Hirohisa et al. reported that about 10% of patients could not achieve meaningful neuropathy after nerve catheter therapy. Functional recovery, this value reached 26% in the study of Weber and his colleagues; it shows that there are still a large number of patients who cannot benefit from the existing nerve catheter therapy in clinical practice; some people in previous studies have reported that it can be achieved by applying an electric field to the external electrode of the catheter However, the external electrode itself will cause secondary trauma, which will affect the difficulty of wound care for patients, increase the discomfort of patients, and easily lead to infection; this application uses the method of magnetic stimulation combined with conductive nerve guides, and uses electromagnetic induction to compensate Overcome the difficult problems in this field, and promote nerve repair without external electrodes

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