Composite cone beam CT enhanced contrast agent and preparation method thereof

Abstract

The invention relates to the technical field of oral and maxillofacial medical imaging technologies, in particular to a composite cone beam CT enhanced contrast agent which comprises an X-ray imaging agent sodium iodide, distilled water, a hydrophilic medicinal penetrant dimethyl sulfoxide, an organic solvent, a fungicide ethanol, a lipophilic penetrant and a flavoring agent ethyl acetate. The imaging component content of the contrast agent can be adjusted, and the contrast agent can be recognized with different densities of tooth tissues and various fillers, so that the accuracy, sensitivity and specificity of CBCT on tooth subfissure diagnosis are further improved; a preparation method of a composite cone beam CT enhanced contrast agent comprises the following steps: firstly, slowly dissolving 25 g of 99% dimethyl sulfoxide in 10 g of distilled water, stirring and dissolving to obtain a homogeneous solution, then adding 10 g of 99% ethanol, stirring and dissolving to obtain a homogeneous solution, then adding 10 g of 99% ethyl acetate, stirring to obtain a homogeneous solution, and finally adding 10 g of 99% ethyl acetate, stirring to obtain a homogeneous solution; finally, 30 g of 99% sodium iodide is added and dissolved into a homogeneous solution, and compared with meglumine diatrizoate, the contrast agent prepared through the method has the advantages that the developing rate and the developing depth are obviously improved.

Description

technical field [0001] The invention relates to the technical field of oral and maxillofacial medical imaging, in particular to a compound cone-beam CT enhanced contrast agent and a configuration method thereof. Background technique [0002] Cracked teeth are one of the three main causes of tooth loss in adults following periodontal disease and dental caries. At present, cracked teeth in the broad sense are divided into 5 categories: enamel surface cracks, cusp fractures, cracked teeth, longitudinally fractured teeth, and vertical root fractures. Facing the fracture line extending in the direction of the apex, the fourth type of cracked tooth refers to the fractured tooth that continues from the crown to the root, and the fifth type of VRF refers to the tooth with a fractured root. [0003] The diagnosis of cracked teeth has important clinical significance for the design of reasonable treatment plan and the judgment of prognosis. However, due to the small and hidden cracks ...

AI Technical Summary

Problems solved by technology

[0003] The diagnosis of cracked teeth has important clinical significance for the design of reasonable treatment plan and the judgment of prognosis. However, due to the small and hidden cracks in cracked teeth, the variety of clinical manifestations in different clinical stages, and overlapping with many dental diseases, The diagnosis of cracked teeth is a clinically troubled problem

In recent years, oral cone-beam CT has made it possible to diagnose cracked teeth due to its extremely high spatial resolution. There is still room for improvement in the accuracy, sensitivity and specificity of CBCT in the diagnosis of cracked teeth

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