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Medicine for treating ketamine addiction

A ketamine and drug technology, applied in the field of anti-addiction drugs, can solve problems such as affecting the addictiveness of ketamine, ketamine is easy to become addictive, lack of drugs for treating addiction, etc., achieve good industrial prospects and public welfare value, and reduce ketamine addiction. Effect

Active Publication Date: 2021-11-02
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The use of ketamine is prone to addiction, endangers health, and even breeds social security problems, so the country is tough on it
But even so, the illicit use of ketamine remains unaddressed, and one of the key reasons is the lack of drugs to treat addiction
According to current knowledge, the transcription factors of the PR domain family are involved in cell differentiation and tumorigenesis, but there are no reports related to ketamine addiction, and there are no reports on the use of shRNA to regulate the expression of Prdm5 to affect ketamine addiction

Method used

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  • Medicine for treating ketamine addiction
  • Medicine for treating ketamine addiction
  • Medicine for treating ketamine addiction

Examples

Experimental program
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Effect test

experiment example 1

[0030] Experimental Example 1 Construction of AAV-shPrdm5 (adeno-associated virus that interferes with Prdm5 gene expression) of the present invention

[0031] 1. Preparation of recombinant vector

[0032] (1) Carrier information:

[0033] Plasmid name: H7055

[0034] Gene name: Prdm5, a zinc finger protein gene containing PRDI-BF1 and RIZ domains

[0035] Gene species: Mus musculus

[0036] Gene length: 350bp

[0037] Cloning vector: AOV021pAAV-CMV-MCS-3FLAG

[0038] Post-construction element: AAV-U6-shRNA (Prdm5)

[0039] Basic scheme: annealing, enzyme digestion and ligation

[0040] (2) Materials and methods

[0041] 1. Instruments and equipment

[0042]

[0043] 2. Experimental reagents

[0044]

[0045]

[0046] 3. Experimental method

[0047] (1) Design the target sequence (target sequence) according to the target gene Prdm5 as follows: CCACTGTG ATGCCACATTT (SEQ ID NO.1), GGAGCACAGGAAGATTCAT (SEQ ID NO.2), GCCCATATTGTGGCCAGAA (SEQ ID NO.3).

[0048] ...

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Abstract

The invention discloses a medicine for treating ketamine addiction, and belongs to the field of anti-addiction medicines. The invention discloses a medicine for treating ketamine addiction. The medicine takes a substance for targeted interference of Prdm5 expression as an active ingredient. The invention provides an effective solution for ketamine addiction, and has good industrial prospect and public benefit value.

Description

technical field [0001] The invention belongs to the field of anti-addiction drugs. Background technique [0002] Ketamine, whose chemical name is 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone, is usually in the form of its hydrochloride salt, which is a white crystalline powder. Ketamine was first used as a non-barbiturate intravenous anesthetic, which has hypnotic and analgesic effects. It is mainly used clinically for anesthesia induction and auxiliary anesthesia during minor operations, pediatric examinations, or diagnostic operations. Immediately after the intravenous or intramuscular injection, the human body appears confused, like falling into a dream, but eyes can still be opened, the muscle tension increases and becomes numb, and it is no longer sensitive to changes in the surrounding environment, but the pain sensation completely disappears, and consciousness and sensation are separated. [0003] The use of ketamine is prone to addiction, endangers health, and ev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61P25/36
CPCA61K48/005A61K48/0008A61K9/0019A61P25/36Y02A50/30
Inventor 岑小波徐薇
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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