GMP compliance high-throughput intelligent biological medicine production system

Abstract

The invention relates to the technical field of biological medicine production, in particular to a GMP compliance high-throughput intelligent biological medicine production system. The GMP compliance high-throughput intelligent biological medicine production system comprises a detection cabin, a transfer discharging cabin, a feeding cabin, a culture cabin, a central cabin, a first liquid preparation cabin, a storage cabin, a second liquid preparation cabin, a laminar flow air return pipeline and a laminar flow air return cabin. The transfer discharging cabin is arranged on the right side of the end part of the detection cabin, the culture cabin is arranged on the left side of the feeding cabin, the central cabin is arranged on the rear side of the culture cabin, the second liquid preparation cabin is arranged on the rear side of the central cabin, the storage cabin is arranged on the right side of the second liquid preparation cabin, and the first liquid preparation cabin is arranged on the right side of the storage cabin; according to the GMP compliance high-throughput intelligent biological medicine production system, different operation areas are reasonably arranged and isolated, different technological operations such as important material transfer, liquid operation, culture and the like are executed in a completely closed and airtight cabin body, and full-automatic research, development and production of biological medicines are realized in combination with an intelligent dispatching system, an intelligent operation system and an intelligent data acquisition system.

Description

technical field [0001] The invention relates to the technical field of biopharmaceutical production, in particular to a GMP-compliant high-throughput intelligent biopharmaceutical production system. Background technique [0002] CAR-T, TCR-T, TI L and other new biopharmaceuticals (immune cell drugs) are developing rapidly, and there are continuous new drugs on the market domestically and globally, requiring large-scale and personalized production to meet the individualization of patients Medication needs. New types of biological drugs, such as customized protein drugs, nucleic acid drugs, and gene virus drugs, are produced based on various types of carrier cells, and require a highly safe and high-throughput production model to meet the needs of personalized drugs. [0003] The complete process involves multiple process steps such as sample introduction, consumable transfer, medium feeding, isolation culture, daily test sampling, test sample transfer, sample mixing, centrif...

AI Technical Summary

Problems solved by technology

However, the equipment can only complete the operation of a single sample in a single period of time, which cannot meet the large-scale multi-batch parallel production, and the personalized production needs of a large number of patients still cannot be effectively met

The existing semi-automated desktop laboratory equipment, which mainly relies on imports, binds the process flow and supporting consumables, which limits the rapid iterative development of new processes, and at the same time further increases the cost of drugs, making it difficult for end users to afford new biological drugs, which limits the rapid development of the industry , so a GMP-compliant high-throughput intelligent biopharmaceutical production system is needed to improve the above problems

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