Micro-needle array with micro-pores, and preparation method thereof

Abstract

The invention discloses a micro-needle array with micro-pores, and a preparation method thereof. Micro-needle groove and columnar protrusion machining is carried out on an upper die and a lower die through a laser etching method or an MEMS micro-machining method, after a micro-needle and micro-pore integrated forming die is obtained, polymer is injected into the die through hot press forming, and the micro-needle array with the micro-pores is manufactured. A laser etching method or an MEMS micro-machining method or the like can be adopted to carry out micro-needle groove machining on the upper die to obtain a micro-needle die, then the micro-needle die is subjected to injection molding to prepare the micro-needle array, and then mechanical trepanning is carried out to form the micro-needle array with micro-pores. The micro-pores penetrate through the substrate, the micro-pores and the micro-needles in the shapes of cones or pyramids and the like are arranged on the same substrate to form a micro-needle array structure with the micro-pores, and the micro-pores can be single-pore-penetrating or porous-dispersing. The disadvantage that the polymer hollow microneedle is difficult to manufacture is made up, the microneedle and the micropores are integrated, and the administration amount, the administration rate and the continuity are greatly improved.

Description

technical field [0001] The invention relates to the field of beauty technology, in particular to a microneedle array with microholes on the head of a beauty instrument and a preparation method thereof. Background technique [0002] In recent years, microneedle, as a transdermal technology, has emerged in the consumer market and has attracted widespread attention in the fields of medical cosmetology and other fields. Generally, the application of drugs on the skin surface will be hindered by the stratum corneum, and the drugs cannot be fully absorbed by the skin. The microneedles can penetrate the epidermis to generate a large number of microscopic channels, thereby supplying the active ingredients of the drug to the subcutaneous layer. Microneedle transdermal administration causes almost no trauma to the skin, and even if it does, it will recover quickly without pain. [0003] The microneedles can be made of different materials, such as silicon microneedles, polymer micron...

AI Technical Summary

Problems solved by technology

However, solid microneedles cannot be administered directly by injection. They need to be coated with drugs, and the dosage depends on the amount of coating, which greatly limits the rate and continuity of administration.

Hollow microneedles can solve the above problems and provide continuous drug delivery in a way similar to injection, but hollow microneedles are difficult to manufacture for polymer materials

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