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A kind of composition with gastric mucosal injury protection effect and preparation method thereof

A protection effect and gastric mucosal injury technology, which is applied to the composition having gastric mucosal damage protection effect and the field of preparation thereof, can solve the problems of human body being prone to tolerance, cure the symptoms but not the root cause, and reduce the curative effect, and achieve the gastric mucosal damage protection effect. Obvious, obvious effect, the effect of enhancing resistance

Active Publication Date: 2022-07-19
HEBEI YUZHILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs often have side effects, and long-term use is prone to human tolerance, curative effect decline, and there are problems of recurrent attacks, treating the symptoms but not the root cause, while traditional Chinese medicine is mainly for maintenance, focusing on recuperation, treating the symptoms and the root cause

Method used

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  • A kind of composition with gastric mucosal injury protection effect and preparation method thereof
  • A kind of composition with gastric mucosal injury protection effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0040] Preparation Example 1: Hericium erinaceus extract

[0041] 1) get dry Hericium erinaceus, pulverize, pass through 120 mesh sieves, obtain Hericium erinaceus dry powder;

[0042] 2) adding the dried Hericium erinaceus powder to deionized water and boiling for 30-45min, stirring continuously during the boiling process, centrifuging, and separating the supernatant a;

[0043] 3) adding deionized water to the sediment and boiling for 30-45min, stirring continuously during the boiling process, centrifuging, and separating the supernatant b;

[0044] 4) The supernatant a and the supernatant b were mixed and concentrated, and freeze-dried to obtain the Hericium erinaceus extract.

preparation example 2

[0045] Preparation Example 2: Morel Extract

[0046] 1) get Morchella, wash and dry it, pulverize it through a 100-mesh sieve, obtain powder, add the 5′-phosphodiesterase liquid of 0.1-1% powder weight to the powder, at 50 ° C, the pH is. Under the conditions of 5-6, enzymolysis was carried out for 2h, and then the enzyme was inactivated, and filtered to obtain the first enzymolysis solution of Morchella spp. and the first filter residue;

[0047] 2) Add 1-5% papain solution by weight of the first filter residue to the first filter residue, enzymolysis for 1.5h at 45° C. under the condition of pH 4.5-5.5, then inactivate the enzyme, filter to obtain Morchella The second enzymatic hydrolyzate and the second filter residue;

[0048] 3) Add 0.1-0.5% 5'-phosphodiesterase solution by weight of the second filter residue to the second filter residue, enzymolysis for 2h at 50-55°C and pH 6-7, and then inactivate the enzyme , filtered to obtain the third enzymatic hydrolyzate of More...

preparation example 3

[0050] Preparation Example 3: Rhizoma Rhizoma Extract:

[0051] Pulverize the crude Baiji and pass through a 80-100 mesh sieve. Weigh the sieved Baiji powder and add 8-10 times the mass of 95% ethanol for reflux extraction for 3-5 times, each extraction for 0.5-1h, after combining the extracts. Freeze-drying to obtain a dry powdery extract.

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Abstract

The present invention provides a composition with protective effect on gastric mucosal damage, which, in parts by weight, is composed of the following components: 50-70 parts of Hericium erinaceus extract, 40-60 parts of Morchella extract, Rhizoma Rhizoma extract Compared with the prior art, the present invention is based on the theory of traditional Chinese medicine, aiming at the pathogenesis of qi deficiency in the spleen and stomach, and qi deficiency in the spleen and stomach. If the blood is not smooth, the Hericium erinaceus extract, Morchella mushroom extract, Baiji extract, and Bergamot extract are creatively used to form a traditional Chinese medicine composition. King medicine. Morchella and stomach digestion, resolve phlegm and regulate qi; Baiji absorbs astringent and generates muscle, disperses stasis and removes blood stasis, the two digest food and eliminate accumulation, promote muscle and remove rot, regulate qi and dissipate stagnation, they are ministerial medicines together, increase the blood flow of gastric mucosa, Promote oxygen supply, enhance resistance, and smooth the blood flow of the gastric mucosa, so that the body's blood is comfortable. Bergamot is an adjuvant, which has the functions of promoting qi, nourishing the liver, warming the stomach, strengthening the spleen, and relieving vomiting. Sasuke's work.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition with protective effect on gastric mucosal damage and a preparation method thereof. Background technique [0002] With the accelerated pace of life in modern society, people are under more and more social, psychological and work pressures, resulting in a corresponding increase in the incidence of gastric mucosal diseases. The fast-paced lifestyle, intense work and study, and excessive drinking are common causes of gastric mucosal damage. As a worldwide disease, its incidence remains high in both developed and developing countries. According to reports, more than 10% of my country's social population suffer from gastric ulcer, and about 25% suffer from various gastritis. The total number of gastric patients in the country is nearly 300 million. [0003] The gastric mucosal defense mechanism is a multi-angle, multi-level and multi-nat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61K9/48A61K47/44A61P1/04A61K36/07A61K36/062A61K36/752A61K36/185
CPCA61K36/07A61K36/062A61K36/898A61K36/752A61K36/185A61K9/4858A61P1/04A61K2300/00
Inventor 朱志铭赵大鹏张赞李丽丽马辉韩烁培
Owner HEBEI YUZHILIN PHARMA
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