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Oral antibacterial composition containing essential oil and preparation method of oral antibacterial composition

A technology of composition and essential oil, which is applied in the direction of medical preparations containing active ingredients, drug combinations, oral care, etc., can solve problems such as bad taste and slow onset of effect, achieve good taste, inhibit periodontitis, and relieve pain Effect

Active Publication Date: 2021-09-28
山东福瑞达生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned antibacterial preparations of traditional Chinese medicines have slow onset of action and the unique smell of Chinese herbal medicines leads to bad taste

Method used

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  • Oral antibacterial composition containing essential oil and preparation method of oral antibacterial composition
  • Oral antibacterial composition containing essential oil and preparation method of oral antibacterial composition
  • Oral antibacterial composition containing essential oil and preparation method of oral antibacterial composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-7

[0037] The preparation method of embodiment 1-7:

[0038] (1) Add ethanol into a container, stir and add the essential oil composition in sequence, after stirring evenly, add hydrogenated castor oil PEG-60 to obtain phase A;

[0039] (2) Take another container, add enough purified water, add thickener poloxamer or hydroxyethyl cellulose under stirring, stir to form a homogeneous solution, add moisturizer glycerin, pentylene glycol and silanized Sodium hyaluronate, heating and stirring, stirring evenly, adding polyhexamethylene biguanide, stirring to obtain phase B;

[0040] (3) Add phase A into phase B under stirring, stir for 30 minutes, and then add cooling agent menthol, sweetener xylitol and sucrose, and sour agent sodium citrate in turn after uniformity, stir evenly, add water to the specified weight, and obtain Mouthwash.

Embodiment 8～14

[0073] Embodiment 8~14 and comparative example preparation process are as follows:

[0074] (1) Take a container, add ethanol as a solubilizing agent, stir and add lavender essential oil, tea tree essential oil, and garlic essential oil in sequence, stir evenly, add Tween 80 as a solubilizing agent, and obtain phase A;

[0075] (2) Take a container, add enough purified water, add thickener poloxamer, humectant glycerin, pentylene glycol and silanized sodium hyaluronate mixture under stirring, disperse evenly and heat while stirring until the material liquid is uniform After there are no lumps, add the disinfectant chlorhexidine gluconate and stir evenly to obtain phase B;

[0076] (3) Take a small amount of purified water, stir and dissolve the cooling agent menthol, the sweetener xylitol, aspartame, and the sour agent sodium citrate to obtain phase C;

[0077] (4) Slowly add phase A to phase B under stirring. After stirring and mixing evenly, take phase C and add the mixture...

Embodiment 8～14

[0087] Bacteriostasis experiments (Staphylococcus aureus ATCC6538, Candida albicans ATCC10231, Escherichia coli ATCC8793) were carried out for Examples 8-14 and Control Example 3.

[0088] The test result of embodiment 8~14 and comparative example 3 is shown in table 4;

[0089] Table 4 Experimental results of oral antibacterial gel

[0090]

[0091]

[0092]

[0093] Note: There is no antibacterial effect if the logarithmic value of killing is less than 3.00.

[0094] (4) Analysis of results

[0095] Through investigation at 37° C. for 90 days, it was shown that the contents of Examples 8-13 and Comparative Example 3 all had small fluctuations, which were within an acceptable range.

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Abstract

The invention discloses an oral antibacterial composition containing essential oil and a preparation method of the oral antibacterial composition. The oral antibacterial composition takes disinfectant polyhexamethylene biguanide, chlorhexidine gluconate and the like and an essential oil composition of lavender essential oil, tea tree essential oil and garlic essential oil as main effective ingredients, has a good antibacterial effect, can effectively inhibit periodontitis and relieve pain, can resist inflammation and refresh breath, and has a good taste. The product has good stability, the mouthwash is convenient to use at any time, and the gel can quickly eliminate oral mucosa inflammation at a fixed point and is convenient to use.

Description

technical field [0001] The invention relates to an oral antibacterial composition containing essential oil and a preparation method thereof, belonging to the technical field of oral care and health care. Background technique [0002] Bad breath and oral ulcers are often related to the growth of bacteria in the mouth, and food residues will aggravate the growth of bacteria in the mouth. Office workers often fail to brush their teeth in time after lunch, which will aggravate the growth of bacteria in the mouth. At present, oral cleaning products emerge in endlessly, mainly chemical disinfectants (such as polyhexamethylene biguanide, chlorhexidine gluconate, etc.) Some disinfectants also have side effects, such as chlorhexidine gluconate products, which have a narrow antibacterial spectrum, and long-term use will make teeth yellow and easy to color. In addition, the extensive use of disinfectants will also have an impact on the environment, especially on aquatic organisms. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/43A61K8/84A61P1/02A61P31/04A61P31/10A61Q11/00
CPCA61K8/922A61K8/84A61K8/43A61Q11/00A61P1/02A61P31/04A61P31/10A61K2800/5922Y02A50/30
Inventor 苏淮禹柳杨素珍韩婷婷刘菲陈玉荣王晓梅崔旭
Owner 山东福瑞达生物股份有限公司
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