Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Traditional Chinese medicine probiotic fermentation products, compounds and compositions and their application in the preparation of products with anti-Helicobacter pylori effect

An anti-Helicobacter pylori and fermented product technology, applied in the field of biomedicine, with low toxic and side effects, excellent anti-Helicobacter pylori effect, and wide application prospects

Active Publication Date: 2022-08-02
深圳海创生物科技有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are few reports on the use of traditional Chinese medicine probiotic fermented products for anti-Helicobacter pylori; therefore, it has important application value to develop a traditional Chinese medicine probiotic fermented product with anti-Helicobacter pylori effect; especially the development of traditional Chinese medicine probiotic fermented products A small molecular compound with novel structure against Helicobacter pylori has more significance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine probiotic fermentation products, compounds and compositions and their application in the preparation of products with anti-Helicobacter pylori effect
  • Traditional Chinese medicine probiotic fermentation products, compounds and compositions and their application in the preparation of products with anti-Helicobacter pylori effect
  • Traditional Chinese medicine probiotic fermentation products, compounds and compositions and their application in the preparation of products with anti-Helicobacter pylori effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of hawthorn-Lactobacillus rhamnosus fermented product, Radix ginseng-Bifidobacterium fermented product and compounds of formula I

[0041] (1) Preparation of hawthorn-Lactobacillus rhamnosus fermentation product:

[0042] The fresh hawthorn was chopped and homogenized (50g), and added to Lactobacillus rhamnosus fermentation medium (800mL) containing 5g / L of yeast powder, 10g / L of peptone, and 15g / L of beef extract for fermentation for 12h. The fermentation product was collected, centrifuged for 10 minutes, the supernatant was collected, and freeze-dried at low temperature to obtain a hawthorn-Lactobacillus rhamnosus fermentation product.

[0043] (2) Preparation of Salvia miltiorrhiza-Bifidobacterium fermentation product:

[0044] Fresh ginseng was chopped into homogenate (80g), and added to the bifidobacteria fermentation medium (1000mL) containing 5g / L of yeast powder, 10g / L of peptone, and 15g / L of beef extract for fermentation for 12h. The fe...

experiment example

[0050] In order to evaluate the compound of formula I (abbreviated as LMRS-1), hawthorn-Lactobacillus rhamnosus fermented product (abbreviated as SZLM), Radix Radix-Bifidobacterium fermented product (abbreviated as SZLM) prepared by the above method of the present invention SSBS) and Hawthorn-Lactobacillus rhamnosus fermented product and Salvia miltiorrhiza-Bifidobacterium fermented product in mass ratio of 1:1 composition (abbreviated as SLSB) have anti-Helicobacter pylori proliferation effect, carry out the following effect embodiment .

[0051] Inoculate Helicobacter pylori into the medium, add LMRS-1, SZLM, SSBS and SLSB respectively to make the final concentrations 0.01mg / mL, 0.05mg / mL, 0.25mg / mL 37 ℃ constant temperature shaker (130r / min) ) culture, take samples every 4h, measure the absorbance value at the wavelength of 595nm of the microplate reader, take the incubation time as the abscissa and the corresponding absorbance value as the ordinate, record the data and dra...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of biomedicine, and specifically discloses a traditional Chinese medicine probiotic fermentation product, a compound and a composition and its application in preparing a product with anti-Helicobacter pylori effect. The traditional Chinese medicine probiotic fermented product is a hawthorn-Lactobacillus rhamnosus fermented product, or a fermented product of Radix S. composed composition. The compound has the structure shown in formula I. Due to the anti-Helicobacter pylori activity of the hawthorn-Lactobacillus rhamnosus fermented product, the Radix Astragali-Bifidobacterium fermented product and the compounds of the structure shown in formula I of the present invention; therefore, they can be used to prepare anti-Helicobacter pylori Helicobacter pylori-acting foods, health products or medicines.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to traditional Chinese medicine probiotic fermentation products, compounds and compositions and their application in preparing products with anti-Helicobacter pylori effect. Background technique [0002] Helicobacter pylori is a Gram-negative microaerophilic bacterium that colonizes the gastric mucosa and can often cause gastritis, gastric ulcers and even gastric cancer. In recent years, the unique advantages of traditional Chinese medicine in the treatment of Helicobacter pylori-related gastric diseases and the eradication of Helicobacter pylori have attracted the attention of scholars. Certain side effects, and due to the existence of plant cell walls, the dissolution of traditional Chinese medicine in the body is less, so that the effective components entering the body are greatly reduced. Studies have shown that probiotics can produce a variety of extracellular enzymes in t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/734A61K36/342A61K36/34A61K36/23A61K31/353A61K45/06A61P31/04A23L33/00C07D311/58
CPCA61K36/734A61K36/342A61K36/34A61K36/23A61K31/353A61K45/06A61P31/04A23L33/00C07D311/58A61K2236/19A23V2002/00A23V2400/175A23V2400/51A61K2300/00A23V2200/32
Inventor 刘志刚刘杰刘晓宇罗强罗敏罗丹王怀玲牛文芳龚苗
Owner 深圳海创生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com