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Probiotic and prebiotics combined fermented milk for treating hyperhomocysteinemia and preparation method and application thereof

A technology of cysteinemia and fermented milk, applied to bacteria, dairy products, and medical preparations containing active ingredients used in food preparation, can solve the problem of untreatable hyperhomocysteinemia, Stability, low bioavailability and other issues, to achieve the effect of reducing plasma cysteine ​​levels and increasing levels

Inactive Publication Date: 2021-09-17
海南麦若尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the folic acid produced by the existing Lactobacillus foliage is unstable, easily decomposed, has low bioavailability, and cannot reach the therapeutic dose of hyperhomocysteinemia, so it cannot treat hyperhomocysteinemia. Therefore, there is an urgent need for a fermented milk combined with probiotics and prebiotics for the treatment of hyperhomocysteinemia and its preparation method and use

Method used

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  • Probiotic and prebiotics combined fermented milk for treating hyperhomocysteinemia and preparation method and application thereof
  • Probiotic and prebiotics combined fermented milk for treating hyperhomocysteinemia and preparation method and application thereof
  • Probiotic and prebiotics combined fermented milk for treating hyperhomocysteinemia and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0028] In this example, Lactobacillus plantarum KLDS 1.0317 was preserved in the Culture Collection Center of Northeast Agricultural University. Galacto-oligosaccharides were obtained from Feihe Company. The prior art source of Lactobacillus plantarum KLDS 1.0317 in the present invention is: in vitro evaluation of the effects of ten strains of Lactobacillus on immune cell activity [J]. Food Industry Science and Technology, 2018, 01(39): 312-317.

[0029] A fermented milk combined with probiotics and prebiotics for the treatment of hyperhomocysteinemia, including Lactobacillus plantarum KLDS 1.0317 and galactooligosaccharides; the concentration of the galactooligosaccharides is 2mg / 100mL, and its polymerization The degree is 5; the number of said Lactobacillus plantarum KLDS 1.0317 is ≥1×10 8 CFU / mL.

[0030] Galactooligosaccharides GOS with different degrees of polymerization (3, 4, 5, 6, 7, 8) were added to the MRS liquid medium, and then Lactobacillus plantarum KLDS 1.0317...

Embodiment 2

[0059] A fermented milk combined with probiotics and prebiotics for the treatment of hyperhomocysteinemia, including Lactobacillus plantarum KLDS 1.0317 and galactooligosaccharides; the concentration of the galactooligosaccharides is 2mg / 100mL, and its polymerization The degree is 5; the number of said Lactobacillus plantarum KLDS 1.0317 is ≥1×10 8 CFU / g.

[0060] A use of fermented milk combined with probiotics and prebiotics for treating hyperhomocysteinemia in the preparation of medicines, health products or food for preventing and / or treating and alleviating hyperhomocysteinemia.

[0061] Use of the fermented milk for increasing serum folic acid levels in homocysteinemia.

[0062] Use of the fermented milk for increasing the serum level of 5-MTHF in homocysteinemia.

[0063] Use of said fermented milk for increasing folic acid levels in homocysteinemic liver.

[0064] Use of said fermented milk for increasing the level of 5-MTHF in the liver of homocysteinemia.

[0065...

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Abstract

The invention discloses probiotic and prebiotics combined fermented milk for treating hyperhomocysteinemia. The probiotic and prebiotics combined fermented milk comprises lactobacillus plantarum KLDS 1.0317 and galactooligosaccharide; the concentration of the galactooligosaccharide is 2mg / 100mL, and the polymerization degree of the galactooligosaccharide is 5; and the number of the lactobacillus plantarum KLDS 1.0317 is greater than or equal to 1*10<8>CFU / mL or greater than or equal to 1*10 <8>CFU / g. The invention further discloses a preparation method and application of the probiotic and prebiotics combined fermented milk for treating hyperhomocysteinemia. According to the invention, the lactobacillus plantarum KLDS 1.0317 and galactooligosaccharide compound can be used for effectively treating a hyperhomocysteinemia mouse, increasing the levels of folic acid and 5-MTHF in blood and liver of the hyperhomocysteinemia mouse and reducing the level of cysteine in plasma of the hyperhomocysteinemia mouse.

Description

technical field [0001] The invention relates to fermented milk combined with probiotics and prebiotics for treating hyperhomocysteinemia, a preparation method and application thereof, and belongs to the technical field of microorganisms. Background technique [0002] Hyperhomocystinemia (HHcy) is a widespread public health problem, especially in developing countries, bringing serious health problems and socioeconomic burden. When folic acid (FA) is deficient in the body, the metabolism of homocysteine ​​in the blood is blocked and HHcy is triggered, which can cause a large number of diseases, such as hypertension, stroke, depression, Alzheimer's disease and diabetes. Therefore, supplementing folic acid has become an important means of treating HHcy. [0003] Humans lack the gene to synthesize folic acid, so they can only supplement folic acid through external intake or metabolic synthesis by microorganisms in the intestine. There are two main forms of folic acid supplement...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A23C9/13A61P3/00A61P7/00A61K31/702
CPCA61K35/747A61K31/702A23C9/1307A61P3/00A61P7/00A23V2400/169A61K2300/00
Inventor 李柏良赵丽娜陈庆学
Owner 海南麦若尔生物科技有限公司
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