Application of rpl26 protein in prediction of good response to superovulation in cynomolgus monkeys

A technology of RPL26, superovulation, applied in the field of superovulation, can solve the problem of unclear interaction and other problems

Active Publication Date: 2022-04-26
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current research on the relationship between RPL26 protein and superovulation has not been reported, mainly focusing on the role of ribosomal protein and mosquito fecundity.
Therefore, the interaction between RPL26 and ovaries, oocytes, etc. during superovulation is not yet clear

Method used

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  • Application of rpl26 protein in prediction of good response to superovulation in cynomolgus monkeys
  • Application of rpl26 protein in prediction of good response to superovulation in cynomolgus monkeys

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Embodiment Construction

[0023] Specific embodiments of the present invention will be further described below. It should be noted here that the descriptions of these embodiments are used to help understand the present invention, but are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not constitute a conflict with each other.

[0024] The test methods used in the following experimental examples are conventional methods unless otherwise specified; the materials and reagents used are commercially available reagents and materials unless otherwise specified.

[0025] 1. Superovulation experiment process

[0026]Observe the physiological state of adult female cynomolgus monkeys in the target monkey group every day, and register the cage number and monkey number on the first day when menstruation occurs. On the 1st to 4th days of menstruation, ven...

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Abstract

The invention relates to the application of RPL26 protein in the prediction of good response to superovulation in cynomolgus monkeys, and belongs to the technical field of superovulation. The first day of the successful superovulation group and the fifth day of the successful superovulation group are analyzed by the method of proteomics. , Superovulation failure group on day 1 and superovulation failure group on day 5 for bioinformatics analysis to obtain the differential protein among the groups. From the study of protein level, the changes of protein expression revealed in the blood of superovulated monkeys were explored. In superovulation in cynomolgus monkeys, the presence of RPL26 protein on day 5 in the failed superovulation group but not in the successful superovulation group may suggest poor response during superovulation Ribosome stress occurs in cynomolgus monkeys, which affects the cell cycle process, resulting in the growth and development of oocytes being affected during superovulation, which is not conducive to superovulation. Therefore, the RPL26 protein has become a new molecule for predicting a good response to superovulation in cynomolgus monkeys, and has practical application value.

Description

technical field [0001] The invention relates to the technical field of superovulation, and more specifically, relates to the application of RPL26 protein in predicting good response to superovulation in cynomolgus monkeys. Background technique [0002] Superovulation refers to the use of exogenous hormones to stimulate the ovaries of female animals, to promote the simultaneous growth and development of multiple follicles in the ovary, and finally to obtain multiple mature oocytes. In cynomolgus monkeys, only one dominant follicle matures and ovulates during the natural menstrual cycle. If the superovulation technique is used during the menstrual period, the number of ovulated oocytes can be increased from 1 to 10-20 or even more. Mature oocytes are important materials for research on human diseases, genetic engineering and embryo engineering. However, the number of qualified oocytes obtained through natural cycle is extremely small, which is far from meeting the experiment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 杨世华刘保臻侯润杰
Owner SOUTH CHINA AGRI UNIV
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