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Herba lycopi extract as well as preparation method and application thereof

An extract, the technology of Zeilan, applied in the field of medicine, can solve the problems of restricting the application of HRT, and achieve the effects of preventing and/or treating osteoporosis, increasing bone density, and improving the microstructure of bone tissue

Active Publication Date: 2021-08-24
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These adverse effects limit the application of HRT

Method used

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  • Herba lycopi extract as well as preparation method and application thereof
  • Herba lycopi extract as well as preparation method and application thereof
  • Herba lycopi extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0113] Preparation Example 1: Preparation of Eupatorium Extract 1

[0114] 1. Raw materials, reagents and instruments

[0115] Zeilan traditional Chinese medicine decoction pieces, 60% (v / v) ethanol solution.

[0116] 2. Preparation steps of Eupatorium extract 1:

[0117] (1) Soak 4kg Zeilan traditional Chinese medicine decoction pieces in 60% (v / v) ethanol solution of 10-12 times the weight for about 12 hours, heat and reflux for extraction, extract 4 times, and reflux for 1 hour each time;

[0118] (2) The product obtained in step (1) is combined and filtered to obtain an extract;

[0119] (3) Concentrate the extract obtained in step (2) under reduced pressure at a temperature of 40° C. to 60° C. to obtain an extract, which is Eupatoria extract 1.

preparation example 2-6

[0120] Preparation Example 2-6: Preparation of Eupatorium Extract 2-6

[0121] 1. Raw materials, reagents and instruments

[0122] Zeilan traditional Chinese medicine decoction pieces, 60% (v / v) ethanol solution, 25% (v / v) ethanol solution, 50% (v / v) ethanol solution, 75% (v / v) ethanol solution, 95% (v / v) ethanol solution v) Ethanol solution, macroporous resin D101 (particle size: 0.3-1.25mm, average pore size: ), macroporous resin column (column length×inner diameter: 150cm×15cm), high-speed centrifuge (Beckman).

[0123] 2. Preparation steps of Eupatorium extract 2-6:

[0124] (1) Soak 20kg Zeilan traditional Chinese medicine decoction pieces in 60% (v / v) ethanol solution of 10-12 times the weight for about 12 hours, heat and reflux for extraction, extract 4 times, and reflux for 1 hour each time;

[0125] (2) The product obtained in step (1) is combined and filtered to obtain an extract;

[0126] (3) Concentrate the extract obtained in step (2) under reduced pressure...

preparation example 7

[0136] Preparation Example 7: Preparation of Eupatorium Extract 7

[0137] 1. Raw materials, reagents and instruments

[0138] Zelan traditional Chinese medicine decoction pieces, Buchner's funnel, suction filter bottle.

[0139] 2. Eupatorium extract 7 preparation steps:

[0140] (1) Soak 500g Zeilan traditional Chinese medicine decoction pieces with 10-12 times the weight of water for about 12 hours, heat and reflux for extraction, reflux for 2 hours, and extract once;

[0141] (2) The products obtained in step (1) are combined, filtered through gauze, and then suction-filtered with a Buchner funnel to obtain an extract;

[0142] (3) Concentrate the extract obtained in step (2) under reduced pressure at 40°C-60°C to obtain the extract, which is Eupatoria extract 7.

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Abstract

The invention belongs to the field of medicines, and relates to a herba lycopi extract as well as a preparation method and application thereof. Specifically, the invention relates to the method for preparing the herba lycopi extract, and the method comprises the following steps: (1) extracting herba lycopi by using a 25-95% ethanol solution to obtain an extracting solution; (2) concentrating the extracting solution to obtain a first concentrate; the invention also relates to the herba lycopi extract prepared by the preparation method. The herba lycopi extract disclosed by the invention has a good anti-osteoporosis effect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an eupatorium extract, its preparation method and application. Specifically, the present invention relates to the medicinal use of Eupatorium extract. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a systemic bone metabolic disease caused by multiple factors, characterized by decreased bone mass per unit volume and destruction of bone tissue microstructure, resulting in increased bone fragility and susceptibility to fracture. The National Institutes of Health defines osteoporosis as a skeletal disease characterized by impaired bone strength, microarchitectural degeneration of bone tissue (cancellous bone trabeculae become thinner, broken, and reduced in number) and increased risk of fracture. Bone strength is Comprehensive reflection of bone density and bone quality. Osteoporosis can be divided into two categories: primary OP and secondary OP. Both postmenopausal OP and ...

Claims

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Application Information

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IPC IPC(8): A61K36/53
CPCA61K36/53A61K45/06A61P19/10A61P15/12A61K2236/333A61K2236/53A61K2236/51A61K2300/00A61K36/8964A61K9/28
Inventor 周虎陈杰波陈永炎高硕曾志平刘聪巍王镇武
Owner XIAMEN UNIV
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