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Application of cannabis sativa extract and medicine containing cannabis sativa extract

An extract and water extract technology, applied in the field of cancer and inflammation treatment, can solve the problems of low specificity and poor therapeutic effect, and achieve the effect of reducing toxicity and strong specificity

Inactive Publication Date: 2021-08-06
SHANGHAI JIAO TONG UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] One of the purposes of the present invention is to provide an application of cannabis extract in the preparation of anti-tumor drugs or anti-inflammatory drugs, so as to solve the technical problems of low specificity and poor therapeutic effect in the prior art when using cannabis extract for treatment

Method used

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  • Application of cannabis sativa extract and medicine containing cannabis sativa extract
  • Application of cannabis sativa extract and medicine containing cannabis sativa extract
  • Application of cannabis sativa extract and medicine containing cannabis sativa extract

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Molecular-grade water is used as the extractant to extract the flowers and / or seeds of cannabis, and the obtained extract is a water extract (represented by WE below). The extraction procedure is as follows: put 500 mg of cannabis corolla into 5 ml of molecular grade water, heat in a water bath (about 98°C) for 2 hours, then cool at room temperature, filter and extract as follows: 100 μL of molecular grade water is placed in a glass tube, and ultrasonicated for 15 minutes , centrifuge at 3500g for 5min, and inject about 3 μL of the supernatant into the UHPLC-MS / MS system. The extraction method is a prior art and will not be described in detail here.

Embodiment 2

[0040] The flowers and / or seeds of cannabis are extracted using ethanol as an extractant, and the obtained extract is an ethanol extract (hereinafter referred to as AE). The extraction steps are: put 500mg of hemp seeds into 5ml of ethanol, heat in a water bath (about 98°C) for 2 hours, then cool at room temperature, filter and extract as follows: 100μL of ethanol is placed in a glass tube, ultrasonicated for 15min, centrifuged at 3500g After 5 minutes, about 3 μL of the supernatant was injected into the UHPLC-MS / MS system. The extraction method is a prior art and will not be described in detail here. In this embodiment, the extractant is ethanol.

Embodiment 3

[0042] Use n-hexane as extractant to extract the flowers and / or seeds of cannabis, the obtained extract is to prepare n-hexane, use the extraction method described in Example 1 to dry extract the flowers and seeds of cannabis, and extract to obtain n-hexane extraction matter (hereafter expressed by HE). The extraction procedure is as follows: put 500 mg of cannabis corolla into 5 ml of n-hexane, heat in a water bath (about 98 ° C) for 2 hours, then cool at room temperature, filter and extract as follows: 100 μL of n-hexane is placed in a glass tube, ultrasonicated for 15 minutes, Centrifuge at 3500g for 5min, and inject about 3μL of the supernatant into the UHPLC-MS / MS system. The extraction method is a prior art and will not be described in detail here. In this embodiment, the extractant is n-hexane.

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Abstract

The invention relates to the technical field of cancer and inflammation treatment, in particular to application of a cannabis sativa extract and a medicine containing the cannabis sativa extract. According to the application of the cannabis sativa extract in preparation of anti-tumor medicine or anti-inflammatory medicine, the cannabis sativa extract comprises at least two of a water extract, an ethanol extract and an n-hexane extract, the water extract is extracted from a cannabis sativa plant with water as an extracting agent, the ethanol extract is extracted from the cannabis sativa plant with ethanol as an extracting agent, and the n-hexane extract is extracted from the cannabis sativa plant with n-hexane as an extracting agent. The cannabis sativa extract has an anti-proliferation effect on HepG2 cell lines and has a certain effect on relieving toxicity of rats exposed to acute Ni, and particularly, the cannabis sativa extract is combined with various cannabis sativa extracts, so that stronger specificity and toxicity reduction effects can be provided.

Description

technical field [0001] The invention relates to the technical field of cancer and inflammation treatment, in particular to the application of a cannabis extract and medicines comprising the cannabis extract. Background technique [0002] For centuries, cannabis extracts have been used worldwide for many conditions such as pain, nervous system disorders, and more. Cannabis is considered a psychoactive and euphoric compound. Researchers initially applied it to pharmaceuticals. However, its medical use has grown to a great extent over time. Different reports show multiple uses of cannabis for chronic pain, depression, neuropathy, arthritis, multiple sclerosis, Parkinson's disease, sickle cell anemia, Crohn's disease, and more. Cannabis extracts may also be referred to as cannabinoids, a term used to describe nearly 100 terpene-phenolic compounds that fall into three main categories, namely, phytocannabinoids, endocannabinoids, and synthetic cannabinoids. [0003] Endocannab...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P29/00A61P35/00A61K131/00A61K133/00
CPCA61K36/60A61P29/00A61P35/00A61K2236/331A61K2236/333
Inventor 王恒魏冬青阿里夫.马里克穆罕默德·塔希尔·汗
Owner SHANGHAI JIAO TONG UNIV
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