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Compound modified chitin gel preparation and preparation method thereof

A gel preparation and chitin technology, applied in non-central analgesics, anti-inflammatory agents, pharmaceutical formulations, etc., to achieve the effects of promoting wound healing, improving compliance, and good biocompatibility

Pending Publication Date: 2021-08-06
南京先宇科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem of improving the effect of hemostatic products such as oral trauma and maxillofacial surgery and the comfort of patients in clinical applications, the present invention provides a compound modified chitin gel preparation, which can quickly stop bleeding, and at the same time is beneficial to antibacterial and anti-inflammatory The wound heals, and the patient is less likely to have a foreign body sensation when using it

Method used

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  • Compound modified chitin gel preparation and preparation method thereof
  • Compound modified chitin gel preparation and preparation method thereof
  • Compound modified chitin gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The prescription is as follows:

[0033]

[0034] 1, dissolve acetic acid, chitosan in distilled water;

[0035] 2, take a proper amount of distilled water, add Carbum, swelling the cardum gum under stirring;

[0036] 3, dissolve the hydrochloride hydrochloride is dissolved in distilled water;

[0037] 4. Add glycerol, Tween 80 in the first step, Tween 80, then add the third step in the third-step Medica due to solution, stir well.

[0038] 5. Add the drug solution to the carbem collide, stir well, add distilled water to 100 g, add sodium hydroxide tuning pH to 6.8, which is obtained to modify the neutral lidococcal gel.

Embodiment 2

[0040] The prescription is as follows:

[0041]

[0042] 1, dissolve acetic acid, chitosan in distilled water;

[0043] 2, take a proper amount of distilled water, add Carbum, swelling the cardum gum under stirring;

[0044] 3, dissolve the hydrochloride hydrochloride is dissolved in distilled water;

[0045] 4. Add glycerol, Tween 80 in the first step, Tween 80, then add the third step in the third-step Medica due to solution, stir well.

[0046] 5. Add the drug solution to the carbem collant, stir well, add distilled water to 100 g, and sodium hydroxide tuning pH to 6.0, that is, the modified neutral lidococcal gel is obtained.

Embodiment 3

[0048] The prescription is as follows:

[0049]

[0050] 1, dissolve acetic acid, chitosan in distilled water;

[0051] 2, take a proper amount of distilled water, add Carbum, swelling the cardum gum under stirring;

[0052] 3, dissolve the hydrochloride hydrochloride is dissolved in distilled water;

[0053] 4. Add glycerol, Tween 80 in the first step, Tween 80, then add the third step in the third-step Medica due to solution, stir well.

[0054] 5. Add the drug solution to the carbem collide, stir well, add the distilled water to 100 g, and sodium hydroxide tuning pH to 7.2, that is, the modified chitin-containing gel is obtained.

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PUM

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Abstract

The invention provides a compound modified chitin gel preparation and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Specifically, the compound modified chitin gel preparation comprises two active ingredients, namely local anesthetics and chitosan, and pharmaceutically acceptable auxiliary materials. The auxiliary materials comprise a gel matrix, a pH regulator formed by combining acid and alkali, a solubilizer, a humectant and a solvent. The gel preparation not only can stop bleeding, but also can relieve pain, is convenient for a patient to use, is free of foreign body sensation, and can greatly improve the compliance of a patient. The gel disclosed by the invention can be used for sterilizing and disinfecting, promoting the activation of cells, and generating a large amount of collagenous fibers, so that scars are not left on wounds, and the wound healing is promoted. The gel disclosed by the invention has good biocompatibility and biodegradability, which has relatively strong antibacterial and wound healing promoting effects.

Description

Technical field [0001] The present invention belongs to the field of pharmaceutical preparations, and more particularly to a compound modified chitin gel formulation and a preparation method thereof. Background technique [0002] Several but known as a skeleton, a skeletal film such as skeletal and bacteria such as shrimp crab, a white or micro-yellow transparent body, insoluble in water, ethanol and diethyl ether, is 2-acetyl glucose The chemical structure is similar to the natural cellulose, and the molecules except for the presence of a hydroxyl group, and a acetylamino and an amino function group are also contained, which belongs to natural polymer polysaccharides. [0003] [0004] The chitosan can be dissolved in an alkenoic acid after the chitin removal of the acetamide group. The higher the degree of deacetylation of the acetylation, the stronger the biological activity, and when it is degraded to a molecular weight below 100,000, it can be soluble in water, referred to...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/722A61K31/167A61K31/381A61K47/32A61P7/04A61P17/02A61P31/04A61P31/10A61P29/00
CPCA61K9/06A61K31/722A61K31/167A61K31/381A61K47/32A61P7/04A61P17/02A61P31/04A61P31/10A61P29/00A61K2300/00
Inventor 卞君醒
Owner 南京先宇科技有限公司
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