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Application of total glucosides of paeony in preparation of medicine for treating Graves disease

The technology of a drug and total glycosides is applied to the application field in the preparation and treatment of Graves' disease, which can solve the problems of immune regulation disorder and no report on the application of total glycosides of paeony, and achieves the reduction of heart weight, the relief of the degree of thyroid tissue hyperplasia, and the remission of the disease. Effect

Pending Publication Date: 2021-08-03
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Graves' disease is also an autoimmune disease with immune regulation disorder, but so far there has not been any relevant application report of total glucosides of paeony in Graves' disease

Method used

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  • Application of total glucosides of paeony in preparation of medicine for treating Graves disease
  • Application of total glucosides of paeony in preparation of medicine for treating Graves disease
  • Application of total glucosides of paeony in preparation of medicine for treating Graves disease

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Embodiment Construction

[0023] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0024] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

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Abstract

The invention discloses an application of total glucosides of paeony in preparation of a medicine for treating Graves disease. In an adenovirus (A-sub-Ad) induced Graves disease model expressing thyrotrophin receptor A subunit, white paeony root total glycoside feed with different concentrations is fed at different time, the total duration is 10 weeks, and the result shows that TRAb and TT4 levels of mice subjected to high-dose early treatment (500mg / kg / d) are obviously reduced; a thyroid tissue pathological section shows that the hyperplasia degree of thyroid tissue is obviously relieved; and the mouse heart weight is reduced. Therefore, the animal experiment result disclosed by the invention shows that the total glucosides of paeony can effectively relieve the condition of the Graves disease, and the application of the total glucosides of paeony in preparing the medicine for treating the Graves disease is fully supported.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the application of total glucosides of paeony in the preparation and treatment of Graves' disease. Background technique [0002] Graves' disease (GD) is an organ-specific autoimmune disease mediated by thyrotropin receptor (TSHR), and it is also the most common clinical cause of hyperthyroidism. The clinical manifestations of GD are mainly hypermetabolism and thyroid hyperplasia caused by excessive secretion of thyroid hormones. The damage can involve various organs of the body. If not treated properly, it will lead to progressive sexual organ dysfunction, and eventually hyperthyroidism, thyroid crisis, etc. life-threatening complications. The prevalence of GD is as high as 0.5%-2%, and there is an increasing trend in recent years, and the risk of women is 5-10 times that of men. [0003] To date, the pathogenesis of Graves' disease has not been fully elucidated. At present, ...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/65A61P37/02A61P9/00A61P5/16A61K125/00
CPCA61K36/71A61K36/65A61P37/02A61P9/00A61P5/16
Inventor 施秉银伍丽萍谢宝松王静雅德吉措穆
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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