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Application of ferroptosis inhibitor in preparation of preparation for improving motion function of aged individuals

A technology of motor function and ferroptosis, applied in the field of biomedicine, can solve problems such as the pathogenicity of hypertrophy that have been reported

Pending Publication Date: 2021-07-30
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, the pathogenicity of hypertrophy has not been reported in other organs such as skeletal muscle

Method used

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  • Application of ferroptosis inhibitor in preparation of preparation for improving motion function of aged individuals
  • Application of ferroptosis inhibitor in preparation of preparation for improving motion function of aged individuals
  • Application of ferroptosis inhibitor in preparation of preparation for improving motion function of aged individuals

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Experimental program
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Embodiment 1

[0025] experimental method:

[0026] 1. Animal model

[0027] C57BL / 6J mice were purchased from Guangdong Experimental Animal Laboratory Center and placed in temperature- and humidity-controlled and ventilated specific pathogen-free (SPF) cages at the animal facility of Guangdong Institute of Microbiology. All animal handling and procedures were approved by the Animal Care and Use Committee of Guangdong Institute of Microbiology [permission number: GT-IACUC201704071]. All experimental mice were placed on a 12-h light:dark cycle with food and water ad libitum.

[0028] By carrying Pax7-CreER (purchased from JacksonLab, product code: 017763) and Tfr1 fl / fl (purchased from JacksonLab, product code: 028363) alleles of mice were crossed to produce mice with muscle satellite cell-specific Tfr1 deletion. Genotype is Pax7-CreER + / - ;Tfr1 fl / fl were designated as homozygous (Tfr1 SC / KO ); Pax7-CreER - / - ;Tfr1 fl / fl were designated as control mice (Tfr1 SC / WT ). to Tfr1 SC / WT...

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Abstract

The invention discloses an application of a ferroptosis inhibitor in preparation of a preparation for improving the motion function of aged individuals. Through transcriptome sequencing analysis, Tfr1 expression in skeletal muscle and muscle satellite cells is reduced along with age increase. The specific knockout of the Tfr1 muscle satellite cells leads to irreversible inactivation of the muscle satellite cells. The skeletal muscle regeneration process of the Tfr1 muscle satellite cell specific mouse is accompanied by amyotrophy, iron ion accumulation and increase of unsaturated fatty acid biosynthesis, and then skeletal muscle ferroptosis is induced. The senescent skeletal muscle shows that the expression of Tfr1 is reduced, and the surface of an Slc39a14 membrane is enriched, so that the absorption of non-iron transporter binding iron is promoted to be increased, and the occurrence of ferroptosis is promoted. By intraperitoneal injection of the Ferrostatin-1 into aged mice, muscle aplastic disorder and dyskinesia caused by skeletal muscle ferroptosis can be remarkably improved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of Ferrostaine-1 in the preparation of a preparation for inhibiting aging skeletal muscle iron death and improving the motor function of aging individuals. Background technique [0002] Programmed cell death (PCD), such as apoptosis, autophagy and the newly discovered programmed necrosis (also known as necroptosis) is the removal of dead, nonessential or senescent cells during body and organ development / regeneration key process. Skeletal muscle is not only the main organ of exercise, but also participates in the regulation of systemic metabolism. Muscle cell death occurs in several forms, such as apoptosis, necrosis and autophagy. Under regenerative conditions, cell death, clearance and regeneration are precisely regulated, and dysregulation of these processes leads to muscular dystrophy and sarcopenia. Skeletal muscle necrosis occurs under various pathog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/245C12Q1/6883A61P21/00A61K31/138
CPCA61K31/245A61K9/0019C12Q1/6883A61P21/00A61K31/138C12Q2600/158
Inventor 谢黎炜丁红荣刘志红韩木兰刘秉东盘桂花许国焕
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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