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Determining the rising levels of circulating ketone bodies in a physiological fluid

A physiological fluid and level technology, applied in biological testing, blood characterization devices, diagnostic recording/measurement, etc., can solve the problems of not being able to provide users with sufficient and timely measurement results, and being impractical

Pending Publication Date: 2021-07-23
BIOLINQ INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In many cases, this approach is impractical and does not provide users with measurements timely enough to eliminate the need for medical attention, emergency room visits, or hospital admissions

Method used

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  • Determining the rising levels of circulating ketone bodies in a physiological fluid
  • Determining the rising levels of circulating ketone bodies in a physiological fluid
  • Determining the rising levels of circulating ketone bodies in a physiological fluid

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Embodiment Construction

[0047] In healthy individuals, circulating ketone levels are typically well below 0.5 millimolar ("mM"). Slightly elevated ketone levels (i.e., between 0.5 and 1 mM) are usually a sign of ketosis, which often results from fasting or a low-carb diet as the liver clears its fat stores for energy. Healthy individuals are rarely at risk for ketoacidosis (>1 mM, resulting in acidification of the blood due to highly elevated levels of ketone bodies). A lack of insulin, which would otherwise allow glucose to enter cells to fuel them, causes the body to scavenge energy from free fatty acids in the liver, which causes an overproduction of ketone bodies and subsequent acidification of the blood, disrupting acid / base homeostasis. Diabetic ketoacidosis (DKA) is a life-threatening metabolic complication of diabetes with a mortality rate of 2-10%. DKA is typically manifested by prolonged hyperglycemia and overall poor blood glucose management, including inadequate insulin administration, i...

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PUM

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Abstract

Ketoacidosis is a medical emergency that requires swift intervention to avert life- threatening sequel. A body-worn sensor (50) configured to measure the levels of a ketone compound circulating in a physiological fluid of a wearer and capable of generating an alert to the wearer if the level of the circulating ketone compound exceeds a pre-defined level or rate of change is disclosed herein. The sensor (50) preferably includes at least one of an electrochemical sensor, an optical sensor, a galvanic sensor, a voltammetric sensor, an amperometric sensor, a potentiometric sensor, an impedimetric sensor, a resistive sensor, a capacitive sensor, an ultrasonic sensor, a radio-frequency sensor, or a microwave sensor.

Description

technical field [0001] Technologies described herein relate to devices and methods for generating actionable alerts to a user via measurement of circulating ketone body levels in a user's physiological fluids by means of a skin-worn analyte-selective sensor. Background technique [0002] Ketone bodies are water-soluble molecules produced by the liver during excessive consumption of fatty acids as a normal byproduct of energy metabolism during gluconeogenesis—the production of glucose (the body's primary energy source) from noncarbohydrate sources. In healthy individuals, circulating ketone levels are usually low, but during periods of low food intake (fasting), low carbohydrate consumption, starvation, prolonged periods of vigorous exercise, or high alcohol intake, levels of ketone bodies can vary As liver glycogen stocks are depleted and rise; this is commonly known as ketosis and is relatively harmless, new research leads potentially point to the benefits of achieving a ke...

Claims

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Application Information

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IPC IPC(8): A61B5/145G01N33/64
CPCA61B5/14546A61B5/6801A61B5/746A61B5/742
Inventor J·温德米勒J·坦尼T·A·佩泽J·斯乔伦德
Owner BIOLINQ INC
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