Gene detection kit for individualized administration of anti-epileptic drugs and application of gene detection kit

Abstract

The invention belongs to the field of gene detection, and particularly relates to a gene detection kit for individualized medication of anti-epileptic drugs and application of the gene detection kit. The kit provided by the invention mainly comprises a library primer mixed solution, a multiple PCR library amplification buffer solution, a digestion buffer solution, a connection buffer solution, ligase, a specific linker, a HiFi library amplification buffer solution, a positive / negative quality control product, a report system and a specification. The kit provided by the invention can be used for detecting 10 kinds of anti-epileptic clinical common medicines, totally 44 genes and 103 detection sites; and related gene detection and report analysis for predicting the curative effect and the adverse reaction of the antiepileptic drug are realized, and assistance is provided for medication of clinicians.

Description

technical field [0001] The invention belongs to the field of gene detection, and in particular relates to a gene detection kit for individualized medication of antiepileptic drugs and its application. Background technique [0002] Epilepsy is a chronic disease caused by abnormal and excessive hypersynchronized discharge of brain neurons, and its clinical manifestations are motor, sensory, consciousness and autonomic nervous system disorders. According to the World Health Organization (WHO) data, there are currently about 50 million people with epilepsy in the world, of which about 80% are in developing countries, and the prevalence of epilepsy is about 7.2‰; the prevalence of epilepsy in my country is 4‰~8‰, At present, there are about 10 million epilepsy patients in China. Epilepsy, as a neurological disease with a high incidence, is a major killer of human health after cardiovascular and cerebrovascular diseases. [0003] At present, the treatment methods for epilepsy mai...

AI Technical Summary

Problems solved by technology

In order to solve the problem that the existing detection products cover few drugs and genes, and the prediction is not accurate enough, new and effective treatment options are needed for patients; drugs involve many related genes and sites, and the interpretation is complicated, which is not conducive to clinicians' interpretation or utilization The market needs an efficient and convenient antiepileptic drug gene detection kit to improve the accuracy of antiepileptic drug use and reduce the probability of adverse drug reactions. Based on this, the present invention provides an antiepileptic drug. Gene detection kit and its application for individualized medication of epilepsy drugs

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