Fano resonance-based surface-enhanced Raman sensing substrate and production method thereof

A surface-enhanced Raman and Fano resonance technology, applied in the field of optics, can solve the problems of complex preparation, high cost and difficult application.

Active Publication Date: 2021-07-06
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, a variety of nanostructures have been designed to achieve Fano resonance, such as non-concentric ring / disk resonators, nanorod-ring structures, heptamer structures, nanodisk matrices, etc.; however, the preparation is too complicated and the cost is high. problem, difficult to apply

Method used

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  • Fano resonance-based surface-enhanced Raman sensing substrate and production method thereof
  • Fano resonance-based surface-enhanced Raman sensing substrate and production method thereof
  • Fano resonance-based surface-enhanced Raman sensing substrate and production method thereof

Examples

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Embodiment 1

[0042] This embodiment provides a nanosphere-polyethylene glycol-gold film structure surface-enhanced Raman sensing substrate based on Fano resonance, and its structure is as follows figure 1As shown, the surface-enhanced Raman sensing substrate is prepared on a silicon substrate, specifically including: a gold film and nanospheres, wherein the nanospheres are silica nanospheres modified with Avidin (avidin); The surface of the gold film is chemically modified with Biotin-PEG-SH (mercapto-polyethylene glycol-biotin) chemical reagent, and the mercapto group (SH) is strongly chemically connected with the gold film, and PEG (polyethylene glycol) Used to control the length through different molecular weights, Biotin (biotin) and Avidin (avidin) are strongly chemically linked, such as figure 2 shown; and, the surface of the silica nanospheres is coated with a gold-plated layer.

[0043] In this embodiment, in the surface-enhanced Raman sensing substrate structure, the thickness o...

Embodiment 2

[0067] This embodiment provides a nanosphere-polyethylene glycol-gold film structure surface-enhanced Raman sensing substrate based on Fano resonance, and its structure is as follows figure 1 As shown, the surface-enhanced Raman sensing substrate is prepared on a silicon substrate, specifically including: a gold film and nanospheres, wherein the nanospheres are gold nanospheres, and SH-Avidin (mercapto-avidin) is used Carry out chemical modification, make it have Avidin (avidin) modification on the surface; The surface of the gold film adopts Biotin-PEG-SH (mercapto-polyethylene glycol-biotin) chemical reagent to carry out chemical modification, mercapto (SH) and all The gold film is strongly chemically connected, PEG (polyethylene glycol) is used to control the length through different molecular weights, and Biotin (biotin) is strongly chemically connected to Avidin (avidin), such as figure 2 shown.

[0068] Compared with Example 1, this embodiment differs in that: when gol...

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Abstract

The invention belongs to the field of optics, particularly provides a Fano resonance-based surface-enhanced Raman sensing substrate and a production method thereof, and aims to solve the problems of complicated production, high cost and the like of the existing surface-enhanced Raman sensing substrate. According to the surface-enhanced Raman sensing substrate, Fano resonance with asymmetric curve characteristics is generated through resonance coupling of localized surface plasmas between the nanospheres and the gold film and a mirror surface imaging field effect; the nanospheres and the gold film are chemically connected by using avidin and biotin so that a binding force is strong, and the nanospheres and the gold film are stable and not easy to fall off; and in addition, the spectral position and intensity of the Fano dip can be regulated and controlled by changing parameters such as the sphere diameter of the nanospheres and the distance between the nanospheres and the gold film. In conclusion, the surface-enhanced Raman sensing substrate provided by the invention has the advantages of simplicity in production, high sensitivity and good uniformity, and can be used for producing a large-size array structure.

Description

technical field [0001] The invention belongs to the field of optics, relates to surface-enhanced Raman spectroscopy technology, and specifically provides a surface-enhanced Raman sensing substrate based on a Fano resonance nanosphere-polyethylene glycol-gold film structure and a preparation method thereof. Background technique [0002] Surface-enhanced Raman spectroscopy is a technique widely used in molecular analysis and characterization. Surface-enhanced Raman has a very complex system; surface-enhanced Raman substrate surface physical structure and surface electronic structure, laser and rough surface, and the interaction of surface molecules Factors such as interaction, molecular orientation on the surface, bond formation, the surrounding environment of the molecule and the surface, the intensity, frequency, degree of polarization, and polarization direction of the incident laser all have complex effects on Raman spectroscopy. The general surface-enhanced Raman substrat...

Claims

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Application Information

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IPC IPC(8): G01N21/65B82Y15/00B82Y40/00
CPCG01N21/658B82Y15/00B82Y40/00
Inventor 龚天巡魏臻江黄文
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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