Detection method for exciting biological single-molecule terahertz resonance

Abstract

The invention discloses a detection method for exciting biological single molecule terahertz resonance, the detection method comprises a nano plasmon optical tweezers device, and the nano plasmon optical tweezers device comprises an excitation light unit, a surface plasmon excitation unit and a monitoring unit. The surface plasmon excitation unit comprises a slide plated with a gold film, a micro-nano structure solution is arranged on the surface of the slide, and the micro-nano structure solution is used for dynamically controlling and trapping biological single molecules to be detected; the excitation light unit generates terahertz light and emits the terahertz light to the surface plasmon excitation unit, the terahertz light excites biological single-molecule terahertz resonance, the terahertz light is coupled with reflected light of the micro-nano structure solution on the slide, and coupled light obtained after coupling is reflected into the monitoring unit, and high-resolution optical characterization of the biological single-molecule vibration spectrum is obtained. According to the scheme, optical direct measurement is carried out on vibration of the single biological single molecule in the solution, and the terahertz vibration spectrum of the biological single molecule is obtained.

Description

technical field [0001] The invention relates to the technical field of biological single molecule detection, in particular to a detection method for exciting biological single molecule terahertz resonance. Background technique [0002] Biomolecules are important components of living organisms. They not only have biological functions, but also have relatively large molecular weights and complex structures. The complex structure of these biomolecules determines their special properties. Their movements and changes in the body reflect important life functions, such as metabolism, supply of energy and substances needed to maintain life, transmission of genetic information, control of embryonic differentiation, and promotion of growth. development, immune function, etc. The detection and analysis of the structural properties and intermolecular interactions of biomolecules will help people understand the laws of life activities more deeply. [0003] With the development of scien...

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Problems solved by technology

However, the time resolution of plasmon-enhanced spectroscopy depends not only on the signal capability enhanced by nanoparticle probes, but also limited by the readout speed of the spectrometer.

Moreover, in the detection process, it is necessary to obtain multidimensional data of molecular structure, spatial distribution and dynamic process containing complex information from the sample at the same time, but as far as the current technology is concerned, it is difficult to achieve

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