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Dynamic organic gadolinium nanoparticle and application thereof

A nanoparticle, organic gadolinium technology, applied in nanomedicine, nanotechnology, nanotechnology and other directions to achieve the effect of easy modification

Active Publication Date: 2021-07-02
武汉中科极化医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, gadolinium-containing nanoparticle systems as T 2 Contrast agents have rarely been reported

Method used

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  • Dynamic organic gadolinium nanoparticle and application thereof
  • Dynamic organic gadolinium nanoparticle and application thereof
  • Dynamic organic gadolinium nanoparticle and application thereof

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Embodiment 1

[0028]1. Synthesis of gadolinium precursors:

[0029] According to the literature (Liang.G L.et a1.Controlled Self-Assembling of Gadolinium Nanoparticles as Smart Molecular Magnetic Resonance Imaging ContrastAgents.Angew.Chem.Int.Ed., 50,6283-6286, (2011)) disclosed method to synthesize;

[0030] 2. Synthesis of gadolinium intermediates:

[0031] 2.1. Prepare Gd-precursor aqueous solution and 4mM tris(2-carboxyethyl)phosphine (TCEP) aqueous solution with a concentration of 100 μM respectively;

[0032] 2.2. Take 1 mL of 100 μM Gd-precursor aqueous solution, add 1 μL of 4 mM TCEP aqueous solution to it, and stir at room temperature to obtain a gadolinium intermediate, which is designated as Gd-intermediate;

[0033] 3. Preparation of organic gadolinium nanoparticles:

[0034] Prepare Na with a concentration of 0.1M 2 CO 3 aqueous solution, the gadolinium intermediate is replaced with Na 2 CO 3 Adjust the pH value of the aqueous solution to 6.0, and stir at room temperatur...

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Abstract

The invention discloses a dynamic organic gadolinium nanoparticle and application thereof. The nanoparticle is prepared by the following method: 1, respectively preparing a 100 [mu] M gadolinium precursor aqueous solution and a 4 mM tris (2-carboxyethyl) phosphine aqueous solution; 2, mixing the gadolinium precursor aqueous solution and the tris (2-carboxyethyl) phosphine aqueous solution according to the molar ratio of the gadolinium precursor to the tris (2-carboxyethyl) phosphine of 25: 1, and stirring at room temperature to obtain a gadolinium intermediate; and 3, adjusting the pH value of the gadolinium intermediate to 6.0 by using a Na2CO3 aqueous solution, and stirring at room temperature to obtain the dynamic organic gadolinium nanoparticle. The particle size of the nanoparticle can be dynamically changed in different stages of self-assembly, the nano-particles can be used as a T1 contrast agent and a T2 contrast agent in different stages of self-assembly, the same contrast agent can realize positive enhancement and negative enhancement effects of MRI signals, and the detection accuracy can be effectively improved.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a dynamic organic gadolinium nanoparticle and an application thereof. Background technique [0002] Magnetic resonance imaging (MRI), as a non-invasive and radioactive imaging technique, has long been used as one of the important imaging tools for medical diagnosis. Compared with other medical imaging techniques, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), MRI has many advantages, such as non-destructive and non-invasive to the examination object, Three-dimensional image information with high spatial resolution and soft tissue contrast can be acquired. However, MRI has the disadvantage of relatively low sensitivity in medical diagnosis. At present, the sensitivity of MRI is mainly improved by enhancing the imaging contrast. The application of MRI contrast agents can effectively e...

Claims

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Application Information

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IPC IPC(8): A61K49/10A61K49/00A61K49/18B82Y5/00B82Y15/00
CPCA61K49/108A61K49/0002A61K49/1833B82Y5/00B82Y15/00
Inventor 陈世桢孙献平周欣
Owner 武汉中科极化医疗科技有限公司
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