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Preparation method and application of iron-containing organic metal framework functional coating material

An organometallic and coating material technology, applied in coatings, devices for coating liquids on surfaces, medical science, etc., can solve problems such as lack of functional groups, limit the growth of MOFs materials, structural defects, etc., and expand the scope of application , good drug loading capacity, low cost effect

Inactive Publication Date: 2021-06-25
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface of commonly used medical metal materials limits the growth of MOFs due to its own structural defects and lack of functional groups.

Method used

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  • Preparation method and application of iron-containing organic metal framework functional coating material
  • Preparation method and application of iron-containing organic metal framework functional coating material
  • Preparation method and application of iron-containing organic metal framework functional coating material

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preparation example Construction

[0034] A method for preparing an iron-containing organometallic frame functional coating material, comprising the following steps:

[0035] Step 1: preparing a polydopamine coating on the base material;

[0036] First, the medical metal material is cut, and ultrasonically cleaned with sodium lauryl sulfate, absolute ethanol and deionized water in sequence; the cleaning is repeated three times.

[0037] The preparation method of polydopamine coating is as follows:

[0038] S11: placing the matrix material in Tris buffer solution, the buffer solution has a concentration of 10 mM and a pH of 8.5;

[0039] S12: Add dopamine to the solution in step S11, and the concentration of dopamine in the obtained solution is 2 mg / ml;

[0040] S13: React the solution obtained in step S12 for 12 hours at 10-30°C;

[0041] S14: Repeat steps S11-S13 m times, and the base material is dried to obtain the desired polydopamine coating; m is 3. The surface of the obtained matrix material is rich i...

Embodiment 1

[0047] A method for preparing an iron-containing organometallic frame functional coating material, comprising the following steps:

[0048] Step 1: First cut the medical metal material, and then perform ultrasonic cleaning with sodium lauryl sulfate, absolute ethanol and deionized water in sequence; repeat the cleaning three times.

[0049] The matrix material is placed in Tris buffer solution, the concentration of the buffer solution is 10mM, and the pH is 8.5; dopamine is added to the solution, and the final concentration of dopamine in the obtained solution is 2mg / ml; , react for 12 hours; repeat three times, the base material is dried, and the desired polydopamine coating can be obtained.

[0050] Step 2: Place the matrix obtained in step 1 in FeCl with a concentration of 0.06mol / L 3 Solution impregnation; FeCl 3 For solution, the immersion time is 15-20 minutes.

[0051] Step 3: Put the substrate obtained in step 2 in H2 with a concentration of 0.06mol / L 3 15-20min in...

Embodiment 2

[0054] A method for preparing an iron-containing organic metal framework functional coating material loaded with artemisinin, comprising the following steps:

[0055] Step 1: First cut the medical metal material, and then perform ultrasonic cleaning with sodium lauryl sulfate, absolute ethanol and deionized water in sequence; repeat the cleaning three times.

[0056] The matrix material is placed in Tris buffer solution, the concentration of the buffer solution is 10mM, and the pH is 8.5; dopamine is added to the solution, and the final concentration of dopamine in the obtained solution is 2mg / ml; , react for 12 hours; repeat three times, the base material is dried, and the desired polydopamine coating can be obtained.

[0057] Step 2: Place the matrix obtained in step 1 in FeCl with a concentration of 0.06mol / L 3 Solution impregnation; FeCl 3 For solution, the immersion time is 15-20 minutes.

[0058] Step 3: Place the substrate obtained in Step 2 in H 3 The concentration o...

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Abstract

The invention discloses a preparation method and application of an iron-containing organic metal framework functional coating material. The preparation method comprises the following steps: 1, preparing a polydopamine coating on a matrix material; 2, placing the matrix obtained in step 1 into a FeCl3 solution to be soaked; 3, placing the matrix obtained in step 2 into an H3BTC solution to be soaked; and 4, repeating step 2 and step 3 for n times to obtain a required material, wherein n is greater than or equal to 3. The preparation method is simple, easy to operate and low in cost, and the application range of an organic metal framework is widened; and the thickness of the obtained iron-containing metal organic framework functional coating material is easy to control, and the obtained iron-containing metal organic framework functional coating material has good drug loading capacity.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a preparation method and application of an iron-containing organometallic framework functional coating material. Background technique [0002] At present, research on the surface modification of medical metals mainly focuses on anticoagulation, inhibition of smooth muscle cell proliferation, and promotion of endothelial cell growth; inflammation regulation is a new direction for surface modification of cardiovascular materials. Organometallic framework materials can realize the task of loading and releasing anti-inflammatory drugs due to their own porosity and large specific surface area, so organometallic framework coatings can be used to regulate inflammation of cardiovascular materials. Fe 3+ Compared with other metals, it has the advantages of low price, environmental friendliness, and redox performance. The use of MOFs containing Fe particles can regulate ion balance ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B05D7/14B05D7/24A61L31/10A61L31/14A61L31/16
CPCA61L31/10A61L31/146A61L31/16A61L2300/216A61L2300/41A61L2300/606A61L2420/02A61L2420/06B05D7/14B05D7/24C08L79/04
Inventor 翁亚军刘峻峰杨鑫磊章建文陈俊英黄楠
Owner SOUTHWEST JIAOTONG UNIV
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