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Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating mental disorder caused by cerebral trauma

A technology of growth factors and binding proteins, applied in the field of medicine

Pending Publication Date: 2021-06-15
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant research to prove that IGFBP2 can treat mental disorders after TBI

Method used

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  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating mental disorder caused by cerebral trauma
  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating mental disorder caused by cerebral trauma
  • Application of insulin-like growth factor binding protein 2 in preparation of medicine for treating mental disorder caused by cerebral trauma

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Embodiment Construction

[0011] In order to describe the technical content of the present invention more clearly and verify the role of IGFBP2 in mental trauma caused by traumatic brain injury (TBI), further description will be given below in conjunction with specific examples.

[0012] Establishment of a mouse model of brain injury

[0013] C57 mice were housed in a 12-h light / dark rhythm environment with free access to water and food. All behavioral experiments were performed in the light rhythm of the animals.

[0014] First, the CCI mouse model was used to induce anesthesia with isoflurane, and the mouse was fixed with a brain stereotaxic instrument, and anesthesia was maintained, with (AP+1.5mm, L+1.5mm) as the center of the circle, Open a window with a diameter of about 2mm with the cranium, and use the cortical control damage instrument to make the model. The striking parameters are: the diameter of the striking head is 2.0mm, the striking depth is 1.0mm, the striking speed is 2.0m / s, and the ...

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PUM

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Abstract

The invention relates to application of insulin-like growth factor binding protein 2 in preparation of a medicine for treating mental disorder caused by brain trauma. The IGFBP2 intervention can significantly improve anxiety and depression behaviors caused by brain trauma and cognitive function decline behaviors caused by brain trauma.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of an insulin-like growth factor binding protein 2 in preparing a medicine for treating mental disorders caused by traumatic brain injury. Background technique [0002] Traumatic brain injury (TBI) refers to brain injury caused by external mechanical force, such as brain impact, rapid acceleration and deceleration, and sound wave shock, and is one of the main causes of death and disability in humans. There are more than thousands of new TBI cases in the world every year, and the annual treatment cost for traumatic brain injury exceeds 400 billion U.S. dollars, which has caused a heavy burden on individuals, families and society. In addition to being fatal, severe TBI will also cause long-term and serious damage to survivors, including physical disability, emotional disturbance, and cognitive dysfunction. Among them, the mental disorder caused by traumatic brain ...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P25/22A61P25/24A61P25/00
CPCA61K38/1754A61P25/22A61P25/24
Inventor 王振史栋栋张瀛丹
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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