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Cosmetic composition comprising hardy rubber tree bark extract for cooling skin or reducing skin redness

A technology for cosmetic compositions and extracts, applied in the directions of medical preparations, cosmetics, cosmetic preparations containing active ingredients, etc., can solve problems such as minimal problems, and achieve the effects of relieving redness and swelling and inhibiting the rise of skin temperature

Pending Publication Date: 2021-06-04
SK BIOLAND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, studies on PGE2-associated skin thermoregulation using natural product materials are minimal

Method used

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  • Cosmetic composition comprising hardy rubber tree bark extract for cooling skin or reducing skin redness
  • Cosmetic composition comprising hardy rubber tree bark extract for cooling skin or reducing skin redness
  • Cosmetic composition comprising hardy rubber tree bark extract for cooling skin or reducing skin redness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: the preparation of Eucommia bark extract

[0053] After drying and crushing the bark of Eucommia ulmoides, add Eucommia ulmoides and 50% ethanol in a ratio of 1:5 to 50% ethanol, preferably, stir at a temperature of 30-80°C in a ratio of 1:8 by weight for 1- 5 days, preferably, stirring at a temperature of 50° C. for 1 day to obtain Eucommia bark extract. Then, the Eucommia bark extract is filtered using a filter with a mesh size of 0.1-10 um, preferably, with a mesh size of 1-0.3 um. The filtered eucommia bark extract is concentrated at a temperature of about 40˜70° C., preferably at a temperature of 60° C. to prepare a concentrate. The bark extract of Eucommia bark is prepared by adding butanediol to the prepared concentrate to make it 10-50 weight percent, preferably, to make it 30 weight percent.

experiment example 1

[0054] Experimental example 1: content analysis of Eucommia bark extract

[0055] In this experimental example, the content analysis of Table 1 (geniposide) and Table 2 (auucubin), which are active ingredients of the bark extract of Eucommia ulmoides, was carried out on the extract of the above-mentioned Example 1. Utilize high performance liquid chromatography (HPLC) to carry out purity analysis under the condition of record, its result is shown in following table 3 and figure 1 , figure 2 , image 3 and Figure 4 middle.

[0056] Table 1

[0057] Purity Analysis Conditions Using High Performance Liquid Chromatography (HLPC) for Content Analysis of Geniposide

[0058]

[0059] Table 2

[0060] Purity Analysis Conditions Using High Performance Liquid Chromatography (HLPC) for Content Analysis of Aucubin

[0061]

[0062]

[0063] Table 3 utilizes the purity analysis result of high performance liquid chromatography (HLPC)

[0064] Indicator substance...

experiment example 2

[0065] Experimental Example 2: Cytotoxicity Evaluation of Eucommia Bark Extract (MTT Method)

[0066] In this experimental example, the cytotoxicity of the bark extract of Eucommia ulmoides in Example 1 and its active ingredients of geniposide and aucubin were measured.

[0067] After inoculating human immortalized keratinocytes (HaCaT) in a 24-well plate and culturing for 24 hours, the medium of the cultured cells was replaced with a serum free medium, and the samples were treated according to concentration After incubation for 24 hours. After the cultured cells were replaced with a 10-fold diluted 2.5 mg / ml MTT solution for the reaction, the generated MTT-formazan was dissolved by removing the supernatant and adding 1 ml of dimethyl sulfoxide (DMSO) (formazan) crystals, and then use an ELISA Reader to measure the absorbance at 570 nm. Cytotoxicity was expressed as a percentage of absorbance compared to the control group, which is shown in Table 4 below.

[0068] As shown ...

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PUM

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Abstract

The present invention relates to a cosmetic composition comprising a substance derived from a natural product. More particularly, the present invention provides a cosmetic composition for reducing skin redness or for cooling skin and a preparation method therefor, the composition using an extract from hardy rubber tree bark and geniposide and aucubin, which are both contained in the extract from hardy rubber tree bark, to reduce skin redness by lowering the heat due to external exposure or to cool the skin by suppressing an increase in skin temperature.

Description

technical field [0001] The invention relates to a cosmetic composition for refreshing skin or alleviating redness and swelling of skin containing Eucommia bark extract. Background technique [0002] The skin accounts for about 16% of the human body and covers the surface of the human body, and is in direct contact with the external environment, so it is closely related to external factors such as temperature and humidity. The suitable body temperature of the human body is 36.5°C, while the suitable temperature of the skin is 31°C, which is 5-6°C lower. If the suitable temperature is too high or too low, the health of the skin will decline. [0003] Recently, the earth has updated its highest temperature since meteorological observations, and the whole world, including South Korea, continues to experience high temperatures. According to analysis, even if each country implements climate policies at present, it will cause global warming of more than 3 degrees Celsius. As the e...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/60A61Q19/00
CPCA61K8/9789A61K8/602A61Q19/00A61K2800/782
Inventor 朴真省李受莲金艺香李相日李泰峰申松锡
Owner SK BIOLAND CO LTD
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