Preparation method of N-acyl indole compound
A technology of acyl indole compound and carbon monoxide, which is applied in the field of preparation of N-acyl indole compound, can solve problems such as not widely used, and achieve the effects of strong practicability, simple post-processing, and easy operation
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[0030] The present invention will be further described below in conjunction with specific embodiments.
[0031] Add tetrakis(triphenylphosphine)palladium, potassium carbonate, phenol 1,3,5-tricarboxylate, 2-alkynylaniline (II), and aryl iodide into a 35mL Schlenk tube according to the raw material ratio in Table 1 (III) and 2 mL of organic solvent, mixed and stirred evenly, reacted at 60° C. for 24 hours, then added silver oxide, and continued to react at 60° C. for 24 hours, as shown in Table 1. After the reaction is complete, filter, sample with silica gel, and obtain the corresponding N-acylindole compound (I) through column chromatography purification, the reaction process is shown in the following formula:
[0032]
[0033] The raw material addition of table 1 embodiment 1~15
[0034]
[0035]
[0036] Table 2
[0037]
[0038] In Table 1 and Table 2, T is the reaction temperature, t is the reaction time, Me is methyl, tBu is tert-butyl, OMe is methoxy, and ...
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